Inflammation and metabolic disorders
Inflammation and metabolic disorders
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DOI：
10.1097/mco.0b013e32830460c2
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发表时间：
2008-07-01
影响因子：
3.1
通讯作者：
Watson, Andrew D.
中科院分区：
文献类型：
--
作者：
Navab, Mohamad;Gharavi, Nima;Watson, Andrew D.
综述目的营养不良、超重和肥胖已日益成为一个公共卫生问题，因为它们影响许多代谢紊乱，包括心脏病、糖尿病、消化系统紊乱和肾衰竭。研究生活方式的影响，包括健康的营养，将有助于进一步阐明营养不良的不良影响所涉及的机制。最新发现不健康的生活方式，包括营养不良，可导致我们的氧化/氧化还原系统失衡。脂质可以通过脂氧合酶、环加氧酶、髓过氧化物酶和其他酶进行氧化修饰。氧化磷脂可诱导肝脏和其他器官中的炎症分子。这可能会导致炎症，导致冠心病，中风，肾功能衰竭，炎症性肠病，代谢综合征，骨关节疾病，甚至某些类型的cancer.SummaryOur抗氧化剂和抗氧化剂防御机制有助于刺激剂和炎症抑制剂之间的平衡。然而，超过一个点，这些系统可能会不堪重负，最终失败。高密度脂蛋白是毒性氧化脂质形成的有效抑制剂。高密度脂蛋白也是一个有效的系统，刺激基因，其产品是积极的清除，灭活和消除有毒脂质。支持高密度脂蛋白功能应有助于维持这些系统的平衡。希望本报告将阐明为实现这一目标正在开展的一些工作。
Purpose of reviewPoor nutrition, overweight and obesity have increasingly become a public health concern as they affect many metabolic disorders, including heart disease, diabetes, digestive system disorders, and renal failure. Study of the effects of life style including healthy nutrition will help further elucidate the mechanisms involved in the adverse effects of poor nutrition.Recent findingsUnhealthy life style including poor nutrition can result in imbalance in our oxidation/redox systems. Lipids can undergo oxidative modification by lipoxygenases, cyclooxygenases, myeloperoxidase, and other enzymes. Oxidized phospholipids can induce inflammatory molecules in the liver and other organs. This can contribute to inflammation, leading to coronary heart disease, stroke, renal failure, inflammatory bowl disease, metabolic syndrome, bone and joint disorders, and even certain types of cancer.SummaryOur antioxidant and antiinflammatory defense mechanisms contribute to a balance between the stimulators and the inhibitors of inflammation. Beyond a point, however, these systems might be overwhelmed and eventually fail. High-density lipoprotein is a potent inhibitor of the formation of toxic oxidized lipids. High-density lipoprotein is also an effective system for stimulating the genes whose products are active in the removal, inactivation, and elimination of toxic lipids. Supporting the high-density lipoprotein function should help maintain the balance in these systems. It is hoped that the present report would elucidate some of the ongoing work toward this goal.