Eating and hypothalamus changes in behavioral-variant frontotemporal dementia.
Eating and hypothalamus changes in behavioral-variant frontotemporal dementia.
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DOI：
10.1002/ana.22244
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发表时间：
2011-02
影响因子：
11.2
通讯作者：
Halliday, Glenda M.
中科院分区：
文献类型：
--
作者：
Piguet, Olivier;Petersen, Asa;Lam, Bonnie Yin Ka;Gabery, Sanaz;Murphy, Karen;Hodges, John R.;Halliday, Glenda M.
行为变异额颞叶痴呆(BvFTD)是一种进行性神经退行性脑疾病，临床表现为认知、人格和行为的改变。饮食行为的明显障碍，如暴饮暴食和偏爱甜食，也是常见的报告。下丘脑在摄食调节中起着关键作用，但该区域的病理与FTD进食行为之间的关系尚不清楚。这项研究旨在使用两种互补的方法来解决这一问题。首先，18名早期bvFTD患者和16名健康对照接受了高分辨率结构磁共振成像和进食行为评估。在冠状图像上手动跟踪下丘脑的体积。其次，对12例bvFTD病例和6例对照进行了尸检分析。固定的下丘脑组织切片用免疫组织化学染色细胞标记物和调节摄食行为的多肽。对下丘脑的体积、神经元和胶质细胞的数量进行了体视学评估。在两项分析中，bvFTD患者的下丘脑均有显著萎缩。高位摄食障碍患者下丘脑后部明显萎缩。神经元丢失，仅在伴有Tar DNA蛋白-43沉积的bvFTD病例中观察到，也以后方为主。相比之下，食欲素、神经肽Y、可卡因和安非他明调节转录本，以及含有加压素的调节食欲的神经元，在已知参与摄食调节的后部核团中没有表达。下丘脑的变性和随之而来的失调与bvFTD的显著摄食障碍有关。这些发现为治疗模型的发展提供了基础。Ann Neurol 2011
Behavioral-variant frontotemporal dementia (bvFTD) is a progressive neurodegenerative brain disorder, clinically characterized by changes in cognition, personality, and behavior. Marked disturbances in eating behavior, such as overeating and preference for sweet foods, are also commonly reported. The hypothalamus plays a critical role in feeding regulation, yet the relation between pathology in this region and eating behavior in FTD is unknown. This study aimed to address this issue using 2 complementary approaches. First, 18 early stage bvFTD patients and 16 healthy controls underwent high-resolution structural magnetic resonance imaging and assessment of eating behavior. Hypothalamic volumes were traced manually on coronal images. Second, postmortem analyses of 12 bvFTD cases and 6 matched controls were performed. Fixed hypothalamic tissue sections were stained for a cell marker and for peptides regulating feeding behaviors using immunohistochemistry. Stereological estimates of the hypothalamic volume and the number of neurons and glia were performed. Significant atrophy of the hypothalamus in bvFTD was present in both analyses. Patients with high feeding disturbance exhibited significant atrophy of the posterior hypothalamus. Neuronal loss, which was observed only in bvFTD cases with Tar DNA protein-43 deposition, was also predominant posteriorly. In contrast, orexin (hypocretin), neuropeptide Y, cocaine- and amphetamine-regulating transcript, and vasopressin-containing neurons that regulate appetite were spared in posterior nuclei known to participate in feeding regulation. Degeneration and consequent dysregulation within the hypothalamus relates to significant feeding disturbance in bvFTD. These findings provide a basis for the development of therapeutic models. Ann Neurol 2011
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影响因子：
16.2
作者：
GOEDERT, M;SPILLANTINI, MG;CROWTHER, RA
通讯作者：
CROWTHER, RA
影响因子：
11
作者：
Bozeat, S;Gregory, CA;Hodges, JR
通讯作者：
Hodges, JR
影响因子：
12.7
作者：
Hu, William T.;Chen-Plotkin, Alice;Trojanowski, John Q.
通讯作者：
Trojanowski, John Q.
影响因子：
9.9
作者：
Ratnavalli, E;Brayne, C;Hodges, JR
通讯作者：
Hodges, JR
影响因子：
9.9
作者：
Piguet, O.;Hornberger, M.;Hodges, J. R.
通讯作者：
Hodges, J. R.