Lysophosphatidic acid as a phospholipid mediator: Pathways of synthesis
Lysophosphatidic acid as a phospholipid mediator: Pathways of synthesis
复制标题
DOI：
10.1016/s0014-5793(97)00411-0
复制
发表时间：
1997-06-23
期刊：
影响因子：
3.5
通讯作者：
Chap, H
中科院分区：
文献类型：
--
作者：
Gaits, F;Fourcade, O;Chap, H
近年来的研究，包括膜受体编码基因的分子克隆，使亚磷脂酸(LPA)成为一种具有多种生物活性的新型磷脂介体。支持这一观点的另一个强有力的论据是发现LPA是由激活的血小板分泌的，导致其在血液凝固时出现在血清中。代谢途径以及负责LPA产生的酶的特征很差。然而，对文献数据的调查表明，一些有趣的问题可能被用作进一步表征能够降解磷脂酸的磷脂酶A的分子特征的基础。(C)1997年欧洲生化学会联合会。
From very recent studies, including molecular cloning of cDNA coding for membrane receptors, Iysophosphatidic acid (LPA) reached the status of a novel phospholipid mediator with various biological activities. Another strong argument supporting this view was the discovery that LPA is secreted from activated platelets, resulting in its appearance in serum upon blood coagulation. The metabolic pathways as well as the enzymes responsible for LPA production are poorly characterized. However, a survey of literature data indicates some interesting issues which might be used as the basis for further molecular characterization of phospholipases A able to degrade phosphatidic acid. (C) 1997 Federation of European Biochemical Societies.