Growth, metastasis, and expression of CCL2 and CCL5 by murine mammary carcinomas are dependent upon Myd88.
Growth, metastasis, and expression of CCL2 and CCL5 by murine mammary carcinomas are dependent upon Myd88.
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DOI：
10.1016/j.cellimm.2011.10.008
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发表时间：
2012
影响因子：
4.3
通讯作者：
Kurt, Robert A.
中科院分区：
文献类型：
--
作者：
Egunsola, Adetutu T.;Zawislak, Carolyn L.;Akuffo, Afua A.;Chalmers, Samantha A.;Ewer, Jason C.;Vail, Caroline M.;Lombardo, Jeffrey C.;Perez, Dana N.;Kurt, Robert A.
以前我们报道过脂多糖（LPS）治疗小鼠乳腺癌导致肿瘤生长减少。在这里，我们表明LPS处理后的生长下降是通过TLR 4和Myd 88下游的作用介导的。也许更值得注意的是，简单地降低TLR 4或Myd 88水平就足以减缓肿瘤生长速度。此外，降低的Myd 88水平与肺转移的显著减少以及降低的CCL 2和CCL 5表达相关。为了确定抑制Myd 88功能是否也可以改变肿瘤生长和趋化因子表达，我们使用了Myd 88同源二聚化抑制肽。事实上，在四种不同的鼠乳腺癌以及人乳腺癌细胞系MDA-MB-231中抑制Myd 88功能导致生长以及CCL 2和CCL 5表达降低。这些数据暗示Myd 88对于乳腺癌的生长和转移以及至少两种促炎趋化因子的表达是重要的。
Previously we reported that lipopolysaccharide (LPS) treatment of murine mammary carcinomas resulted in decreased growth of the tumors. Here we show the decreased growth following LPS treatment was mediated through effects downstream of TLR4 and Myd88. Perhaps more notably, simply reducing TLR4 or Myd88 levels was sufficient to slow tumor growth rates. Moreover, reduced levels of Myd88 correlated with a significant reduction in lung metastasis as well as decreased CCL2 and CCL5 expression. To determine whether inhibiting Myd88 function could also alter tumor growth and chemokine expression we used a Myd88 homodimerization inhibitory peptide. Indeed, inhibiting Myd88 function in four different murine mammary carcinomas as well as the human breast cancer cell line MDA-MB-231 led to decreased growth as well as CCL2 and CCL5 expression. These data imply that Myd88 is important for growth and metastasis of breast cancer, and expression of at least two proinflammatory chemokines.
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影响因子：
3.7
作者：
Ahtiainen L;Mirantes C;Jahkola T;Escutenaire S;Diaconu I;Osterlund P;Kanerva A;Cerullo V;Hemminki A
通讯作者：
Hemminki A
影响因子：
4.3
作者：
De Sousa, Chiquita Palha;Blum, Christopher M.;Kurt, Robert A.
通讯作者：
Kurt, Robert A.
影响因子：
11.2
作者：
Huang, B;Zhao, J;Xiong, HB
通讯作者：
Xiong, HB
影响因子：
5.5
作者：
Loiarro, Maria;Capolunghi, Federica;Sette, Claudio
通讯作者：
Sette, Claudio
触发人多发性骨髓瘤细胞中的 Toll 样受体 4 可促进增殖并改变细胞对免疫和化疗药物攻击的反应
影响因子：
3.6
作者：
Bao, Hanying;Lu, Peilin;Cai, Zhen
通讯作者：
Cai, Zhen