Goji Berry Effects on Macular Characteristics and Plasma Antioxidant Levels
Goji Berry Effects on Macular Characteristics and Plasma Antioxidant Levels
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DOI：
10.1097/opx.0b013e318205a18f
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发表时间：
2011-02-01
影响因子：
1.4
通讯作者：
Wang, Junkuan
中科院分区：
文献类型：
--
作者：
Bucheli, Peter;Vidal, Karine;Wang, Junkuan
目的.枸杞（Lycium barbarum L.）据称，由于其高抗氧化剂（特别是玉米黄质）含量，玉米黄质有益于视力，尽管这种效果尚未在高质量的人类研究中得到证实。本研究的目的是评估每日补充一种专有的基于牛奶的枸杞配方，乳枸杞（LWB），对老年受试者黄斑特征和血浆玉米黄质和抗氧化能力水平的影响。这是一项双盲、随机、安慰剂对照试验，受试者为健康老年受试者（范围：65 - 70岁），接受13.7 g/d LWB（n = 75）或安慰剂（n = 75）治疗90天。受试者接受直接眼科检查以评估黄斑色素沉着和玻璃疣计数，并抽血测量血浆玉米黄质水平和总抗氧化能力。安慰剂组表现出黄斑色素减退和软性玻璃疣积聚，而LWB组保持稳定。LWB组血浆玉米黄质水平和抗氧化能力均显著增加，分别增加26%和57%，但安慰剂组没有变化。两组均未报告产品相关不良事件。总的来说，每日膳食补充枸杞子90天，增加血浆玉米黄质和抗氧化剂水平，以及防止老年受试者黄斑色素减退和软玻璃疣积累。然而，由于血浆玉米黄质的变化与黄斑特征的变化之间缺乏相关性，其作用机制尚不清楚。（Optom维斯科学2011; 88：257-262）
Purpose. Goji berry (Lycium barbarum L.) is purported to benefit vision because of its high antioxidant (especially zeaxanthin) content, although this effect has not been demonstrated in high-quality human studies. The purpose of this study was to evaluate the effects of daily supplementation with a proprietary milk-based formulation of goji berry, Lacto-Wolfberry (LWB), on macular characteristics and plasma zeaxanthin and antioxidant capacity levels in elderly subjects.Methods. This was a double-masked, randomized, placebo-controlled trial in healthy elderly subjects (range, 65 to 70 years) receiving 13.7 g/d of LWB (n = 75) or placebo (n = 75) for 90 days. Subjects underwent direct ophthalmic examination to assess pigmentation and soft drusen count in the macula and a blood draw to measure plasma zeaxanthin level and total antioxidant capacity.Results. The placebo group demonstrated hypopigmentation and soft drusen accumulation in the macula, whereas the LWB group remained stable. Both plasma zeaxanthin level and antioxidant capacity increased significantly in the LWB group, by 26% and 57%, respectively, but did not change in the placebo group. No product-related adverse events were reported in either group.Conclusions. Overall, daily dietary supplementation with goji berry for 90 days increases plasma zeaxanthin and antioxidant levels as well as protects from hypopigmentation and soft drusen accumulation in the macula of elderly subjects. However, the mechanism of action is unclear, given the lack of relationship between change in plasma zeaxanthin and change in macular characteristics. (Optom Vis Sci 2011; 88:257-262)