Association Between Walking for Exercise and Symptomatic and Structural Progression in Individuals With Knee Osteoarthritis: Data From the Osteoarthritis Initiative Cohort.
Association Between Walking for Exercise and Symptomatic and Structural Progression in Individuals With Knee Osteoarthritis: Data From the Osteoarthritis Initiative Cohort.
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DOI：
10.1002/art.42241
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发表时间：
2022-10
影响因子：
13.3
通讯作者：
Driban, Jeffrey B.
中科院分区：
文献类型：
--
作者：
Lo, Grace H.;Vinod, Surabhi;Richard, Michael J.;Harkey, Matthew S.;McAlindon, Timothy E.;Kriska, Andrea M.;Rockette-Wagner, Bonny;Eaton, Charles B.;Hochberg, Marc C.;Jackson, Rebecca D.;Kwoh, C. Kent;Nevitt, Michael C.;Driban, Jeffrey B.
评估运动步行与膝骨关节炎患者症状和结构进展之间的关系。我们评估了一组年龄在50岁及以上的骨关节炎项目参与者，这是一项2004-2006年以社区为基础的观察性研究。我们关注4个从基线到48个月就诊的二元结果，使用膝关节频繁疼痛和前后半屈曲膝关节x线片的放射学严重程度：1)新的频繁膝关节疼痛，2)Kellgren-Lawrence分级恶化，3)内侧关节间隙狭窄，4)频繁膝关节疼痛改善。在96个月的随访期间（2012-2014），我们使用了一种改良版的历史身体活动调查工具来确定50岁后的步行运动。在1212名参与者中，73%的人通过步行进行锻炼，45%为男性，平均年龄为63.2（7.9）岁，平均体重指数为29.4 (4.6)kg/m2。新的频繁的膝关节疼痛和内侧关节间隙狭窄在行走的患者中较少见(分别为（OR 0.6; 95%CI 0.4 - 0.8）和（OR 0.8; 95%CI 0.6 - 1.0）。在年龄≥50岁的膝骨关节炎患者中，步行锻炼与较少发生频繁的膝关节疼痛相关。这些发现支持应该鼓励患有膝骨关节炎的人进行步行锻炼。此外，我们提供了一个概念证明，即运动步行可以改善疾病，这值得进一步研究。
To assess the relationship between walking for exercise and symptomatic and structural progression in those with knee osteoarthritis. We assessed a nested cohort of participants 50 years or older within the Osteoarthritis Initiative, a community-based observational study enrolled from 2004–2006. We focused on 4 dichotomous outcomes from baseline to 48-month visits using frequent knee pain and radiographic severity on posterior-anterior semi-flexed knee radiographs: 1) new frequent knee pain, 2) Kellgren-Lawrence grade worsening, 3) medial joint space narrowing, and 4) improved frequent knee pain. We used a modified version of the Historical Physical Activity Survey Instrument to ascertain walking for exercise after 50 years of age, administered at the 96-month visit (2012–2014). Of 1212 participants, 73% walked for exercise, 45% were male, mean age = 63.2 (7.9) years, and mean body mass index = 29.4 (4.6) kg/m2. New frequent knee pain and medial joint space narrowing were less common in those who walked ((OR 0.6; 95%CI 0.4 – 0.8) and (OR 0.8; 95%CI 0.6 – 1.0), respectively). In individuals ≥ 50 years old with knee osteoarthritis, walking for exercise was associated with less development of frequent knee pain. These findings support that walking for exercise should be encouraged for people with knee osteoarthritis. Furthermore, we offer a proof of concept that walking for exercise could be disease modifying, which warrants further study.
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影响因子：
7
作者：
Bannuru, R. R.;Osani, M. C.;McAlindon, T. E.
通讯作者：
McAlindon, T. E.
影响因子：
--
作者：
Hunter, David J.;Zhang, Yuqing;Felson, David T.
通讯作者：
Felson, David T.
影响因子：
39.2
作者：
KOVAR, PA;ALLEGRANTE, JP;CHARLSON, ME
通讯作者：
CHARLSON, ME
影响因子：
--
作者：
Chang, A;Hayes, K;Sharma, L
通讯作者：
Sharma, L
DOI：
10.1046/j.1532-5415.2003.51113.x
发表时间：
2003-03-01
影响因子：
6.3
作者：
Talbot, LA;Gaines, JM;Metter, EJ
通讯作者：
Metter, EJ