Acid suppressive drugs and gastric cancer: A meta-analysis of observational studies
Acid suppressive drugs and gastric cancer: A meta-analysis of observational studies
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DOI：
10.3748/wjg.v19.i16.2560
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发表时间：
2013-04-28
影响因子：
4.3
通讯作者：
Park, Sang Min
中科院分区：
文献类型：
--
作者：
Ahn, Jeong Soo;Eom, Chun-Sick;Park, Sang Min
目的：评价抑酸药物使用与胃癌发生之间的关系。方法：使用MEDLINE（PubMed）、EMBASE和科克伦图书馆数据库对2012年6月发表的相关研究进行系统检索。检索包括关于使用组胺2受体拮抗剂（H2 RAs）或质子泵抑制剂与胃癌相关风险的观察性研究，使用校正的比值比（OR）或相对风险和95% CI测量。一个独立的提取进行了两个作者，并达成了共识。结果：4595筛选的文章，11个观察性研究（n = 94558）与5980胃癌患者被纳入最终分析。当所有研究汇总时，抑酸药物使用与胃癌风险增加相关（校正OR = 1.42; 95%CI：1.29-1.56，I-2 = 48.9%，P = 0.034）。H2 RA使用者胃癌的总体风险增加（调整OR = 1.40; 95% CI：1.24-1.59，I-2 = 59.5%，P = 0.008）和PPI使用者（校正OR = 1.39，95% CI：1.19-1.64，I-2 = 0.0%，P = 0.377）。结论：抑酸药物与胃癌发病风险增加有关。抑酸药物对胃癌的作用还需进一步研究。(C)2013年百世登。All rights reserved.
AIM: To evaluate the association between acid suppressive drug use and the development of gastric cancer.METHODS: A systematic search of relevant studies that were published through June 2012 was conducted using the MEDLINE (PubMed), EMBASE, and Cochrane Library databases. The search included observational studies on the use of histamine 2-receptor antagonists (H2RAs) or proton pump inhibitors and the associated risk of gastric cancer, which was measured using the adjusted odds ratio (OR) or the relative risk and 95% CI. An independent extraction was performed by two of the authors, and a consensus was reached.RESULTS: Of 4595 screened articles, 11 observational studies (n = 94558) with 5980 gastric cancer patients were included in the final analyses. When all the studies were pooled, acid suppressive drug use was associated with an increased risk of gastric cancer risk (adjusted OR = 1.42; 95% CI: 1.29-1.56, I-2 = 48.9%, P = 0.034). The overall risk of gastric cancer increased among H2RA users (adjusted OR = 1.40; 95% CI: 1.24-1.59, I-2 = 59.5%, P = 0.008) and PPI users (adjusted OR = 1.39; 95% CI: 1.19-1.64, I-2 = 0.0%, P = 0.377).CONCLUSION: Acid suppressive drugs are associated with an increased risk of gastric cancer. Further studies are needed to test the effect of acid suppressive drugs on gastric cancer. (C) 2013 Baishideng. All rights reserved.