Platelets and Their Interactions with Other Immune Cells.
Platelets and Their Interactions with Other Immune Cells.
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DOI：
10.1002/cphy.c140074
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发表时间：
2015-07-01
影响因子：
5.8
通讯作者：
Rumbaut RE
中科院分区：
文献类型：
--
作者：
Lam FW;Vijayan KV;Rumbaut RE
血小板是无核血细胞，长期以来被认为在止血和血栓形成中起关键作用。除了在血凝块中起作用外，越来越多的证据表明血小板在炎症和免疫中起着重要作用。然而，血小板代表免疫细胞的概念在生理学领域并未得到广泛认可。本文回顾了血小板在炎症和免疫反应中的作用，并强调了它们与其他免疫细胞的相互作用，包括这些相互作用的主要功能后果的例子。
Platelets are anucleate blood cells, long known to be critically involved in hemostasis and thrombosis. In addition to their role in blood clots, increasing evidence reveals significant roles for platelets in inflammation and immunity. However, the notion that platelets represent immune cells is not broadly recognized in the field of Physiology. This manuscript reviews the role of platelets in inflammation and immune responses, and highlights their interactions with other immune cells, including examples of major functional consequences of these interactions.