A HYPOTHESIS CONCERNING THE RELATIONSHIP OF CELLULAR PHARMAKOKINETICS TO OPTIMAL SCHEDULING OF ANTI-CANCER AGENTS
A HYPOTHESIS CONCERNING THE RELATIONSHIP OF CELLULAR PHARMAKOKINETICS TO OPTIMAL SCHEDULING OF ANTI-CANCER AGENTS
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DOI：
10.1159/000226664
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发表时间：
1988-11-01
期刊：
影响因子：
3.5
通讯作者：
MANTHEI, R
中科院分区：
文献类型：
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作者：
WEISS, AJ;MANTHEI, R
众所周知，大多数抗癌剂的毒性程度、毒性类型和治疗毒性比取决于时间表。据推测，最佳方案是在肿瘤细胞和正常细胞之间产生最大可能的药物摄取差异的方案，特别是通过其死亡限制可以给予患者的药物量的那些细胞。可以确定优化肿瘤组织和剂量限制性正常组织之间的药物相对分布的特定药代动力学参数，从而可以允许优化时间表。
It is well recognized that the degree of toxicity, type of toxicity, and therapeutic to toxic ratio of most anti-cancer agents are dependent upon schedule. It is postulated that an optimal schedule is one that creates the largest possible difference in uptake of drug between neoplastic and normal cells, especially those cells that by their death limit the amount of drug that can be given to the patient. Specific pharmacokinetic parameters can be determined that optimize the relative distribution of drug between neoplastic tissues and dose-limiting normal tissues, and thus may permit optimization of schedule.