Reexpression of a developmentally regulated antigen in Down syndrome and Alzheimer disease.
Reexpression of a developmentally regulated antigen in Down syndrome and Alzheimer disease.
复制标题
唐氏综合症和阿尔茨海默病中发育调节抗原的重新表达。
DOI：
10.1073/pnas.85.16.6202
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发表时间：
1988
影响因子：
11.1
通讯作者：
Davies,P
中科院分区：
文献类型：
--
作者：
Wolozin,B;Scicutella,A;Davies,P
ALZ-50是一种单克隆抗体，可识别表观分子量为68千道尔顿（A68）的蛋白质。这种蛋白质存在于阿尔茨海默病患者的大脑中，但在正常成人脑组织中检测不到。我们现在报告说，ALZ-50反应神经元中发现正常胎儿和新生儿的大脑和新生儿个体唐氏综合征的脑组织。反应性神经元在2岁后数量急剧减少，并在患有唐氏综合征的老年人和阿尔茨海默病患者中重新出现。
ALZ-50 is a monoclonal antibody that recognizes a protein of apparent molecular mass 68 kilodaltons (A68). The protein is present in the brains of patients with Alzheimer disease but is not detectable in normal adult brain tissue. We now report that ALZ-50-reactive neurons are found in normal fetal and neonatal human brain and in brain tissue from neonatal individuals with Down syndrome. Reactive neurons decrease sharply in number after age 2 and reappear in older individuals with Down syndrome and in patients with Alzheimer disease.