Oxygen-Sensitive Potassium Channels in Chemoreceptor Cell Physiology Making a Virtue of Necessity
Oxygen-Sensitive Potassium Channels in Chemoreceptor Cell Physiology Making a Virtue of Necessity
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DOI：
10.1111/j.1749-6632.2009.05037.x
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发表时间：
2009-01-01
期刊：
影响因子：
--
通讯作者：
Teresa Perez-Garcia, M.
中科院分区：
文献类型：
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作者：
Gonzalez, Constancio;Vaquero, Luis M.;Teresa Perez-Garcia, M.
自从首次在兔颈动脉小体(CB)化学感受器细胞中描述氧敏K+通道以来，低氧化学转导的分子机制一直是一个活跃的研究领域。因此，已经发现了从氧气传感器到氧气敏感离子通道的转导级联的大量组件。尽管这一过程的终点是相似的，但不同化学感受器组织中所涉及的元素的异质性阻碍了低氧信号转导的统一理论，这一直是争议的来源。然而，当低氧级联反应的这些分子成分回到它们的生理环境中时，很明显，建立一个完整的细胞反应需要多种机制的多样性，这需要几个O-2感应器和几个效应器的协同作用。
The characterization of the molecular mechanisms involved in low-oxygen chemotransduction has been an active field of research since the first description of an oxygensensitive K+ channel in rabbit carotid body (CB) chemoreceptor cells. As a result, a large number of components of the transduction cascade, from O-2 sensors to O-2-sensitive ion channels, have been found. Although the endpoints of the process are analogous, the heterogeneity of the elements involved in the different chemoreceptor tissues precludes a unifying theory of hypoxic signaling, and it has been a source of controversy. However, when these molecular constituents of the hypoxic cascade are brought back to their physiological context, it becomes clear that the diversity of mechanisms is necessary to build up an integrated cellular response that demands the concerted action of several O-2 sensors and several effectors.