Quantitative estimation of quaternary ammonium neuromuscular blocking agents in serum by direct insertion probe chemical ionization mass spectrometry.
Quantitative estimation of quaternary ammonium neuromuscular blocking agents in serum by direct insertion probe chemical ionization mass spectrometry.
复制标题
通过直接插入探针化学电离质谱法定量评估血清中的季铵神经肌肉阻断剂。
DOI：
10.1002/bms.1200130703
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
CastagnoliJr,N
中科院分区：
文献类型：
--
作者：
Castagnoli,KP;Shinohara,Y;Furuta,T;Nguyen,TL;Gruenke,LD;Miller,RD;CastagnoliJr,N
A new method based on selected ion monitoring chemical ionization mass spectrometry was developed to measure the quaternary ammonium neuromuscular blocking agents, pancuronium and vecuronium, in serum. An ion‐pair extraction procedure is utilized to separate the compounds of interest from biological fluids. The intensities of the ion currents produced by the bisamines formed from the drugs and the corresponding deuterated internal standards through thermolytic dequaternization are monitored. The assay shows good linearity over the range of 1–500 ng/ml. This assay has been utilized in a variety of clinical pharmacokinetic studies involving surgical pediatric, geriatric and obstetric patients requiring anesthesia.
