Pattern formation inside bacteria: Fluctuations due to the low copy number of proteins
Pattern formation inside bacteria: Fluctuations due to the low copy number of proteins
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DOI：
10.1103/physrevlett.90.128102
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发表时间：
2003-03-28
影响因子：
8.6
通讯作者：
Rutenberg, AD
中科院分区：
文献类型：
--
作者：
Howard, M;Rutenberg, AD
我们研究了由于参与细菌内模式形成动态的蛋白质的低拷贝数而产生的波动效应。我们集中在一个随机模型的振荡MinCDE蛋白系统调节准确的细胞分裂在大肠杆菌。我们发现，对于一些参数区域，蛋白质浓度足够低，以至于波动对于模式的产生是必不可少的。我们还研究了波动在限制蛋白质浓度水平中的作用。
We examine fluctuation effects due to the low copy number of proteins involved in pattern-forming dynamics within a bacterium. We focus on a stochastic model of the oscillating MinCDE protein system regulating accurate cell division in E. coli. We find that, for some parameter regions, the protein concentrations are low enough that fluctuations are essential for the generation of patterns. We also examine the role of fluctuations in constraining protein concentration levels.