SACCHAROMYCES-CEREVISIAE CELL-CYCLE MUTANT CDC9 IS DEFECTIVE IN DNA-LIGASE
SACCHAROMYCES-CEREVISIAE CELL-CYCLE MUTANT CDC9 IS DEFECTIVE IN DNA-LIGASE
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DOI：
10.1038/274891a0
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发表时间：
1978-01-01
期刊：
影响因子：
64.8
通讯作者：
NASMYTH, KA
中科院分区：
文献类型：
--
作者：
JOHNSTON, LH;NASMYTH, KA
在酿酒酵母中，已分离出许多可能存在 DNA 复制缺陷的突变体 1-3。然而，迄今为止在这些突变体中发现的唯一有缺陷的基因产物是 incdc21，它在胸苷酸合成酶 4,5 中存在缺陷。我们在此报告，Hartwell 分离出的 cdc9-1 作为条件细胞周期突变体6，在参与 DNA 复制和修复的 DNA 连接酶中存在缺陷。最近在裂殖酵母 7 中描述了具有类似特性的突变体。
IN the yeastSaccharomyces cerevisiaea number of mutants potentially defective in DNA replication have been isolated1–3. However, the only defective gene product so far identified in any of these mutants is that incdc21 which is defective in thymidylate synthetase4,5. We report here thatcdc9–l, isolated by Hartwell as a conditional cell cycle mutant6, is defective in a DNA ligase involved in both replication and repair of DNA. A mutant with similar properties has recently been described inSchizosaccharomyces pombe7.