Effect of a very-high-fiber vegetable, fruit, and nut diet on serum lipids and colonic function
Effect of a very-high-fiber vegetable, fruit, and nut diet on serum lipids and colonic function
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DOI：
10.1053/meta.2001.21037
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发表时间：
2001-04-01
影响因子：
9.8
通讯作者：
Connelly, PW
中科院分区：
文献类型：
--
作者：
Jenkins, DJA;Kendall, CWC;Connelly, PW
我们测试了从水果和蔬菜中摄取高纤维的饮食的影响。喂食的水平是那些最初激发了与结肠癌和心脏病预防有关的膳食纤维假说的水平，也可能是在人类进化早期食用的。10名健康志愿者每人服用3种代谢饮食，持续2周。饮食是：高纤维蔬菜、水果和坚果（极高纤维，55 9/1,000千卡）;含淀粉的谷类和豆类（早期农业饮食）;或低脂（当代治疗饮食）。所有饮食均旨在维持体重（平均摄入量，2，577 kcal/d）。与以淀粉为基础的低脂肪饮食相比，高纤维蔬菜饮食导致低密度脂蛋白（LDL）胆固醇的最大降低（33% +/-4%，P < .001）和最大粪便胆汁酸排出量（1.13 ± 0.30 g/d，P = 0.002），粪便体积（906 ± 130 g/d，P <0.001），粪便短链脂肪酸排出量（78 ± 13 mmol/d，P <0.001）。然而，由于粪便体积的增加，粪便胆汁酸的实际浓度在蔬菜饮食中最低（1.2 mg/g湿重，P = .002）。最大的血脂下降发生在1周内。尿甲羟戊酸排泄增加（P = 0.036）的高蔬菜饮食反映大粪便类固醇投掷。我们的结论是，非常高的植物纤维摄入量降低了心血管疾病和结肠癌的风险因素。因此，蔬菜和水果纤维值得进一步详细研究。版权所有2001 W.B.桑德斯公司
We tested the effects of feeding a diet very high in fiber from fruit and vegetables. The levels fed were those, which had originally inspired the dietary fiber hypothesis related to colon cancer and heart disease prevention and also may have been eaten early in human evolution. Ten healthy volunteers each took 3 metabolic diets of 2 weeks duration. The diets were: high-vegetable, fruit, and nut (very-high-fiber, 55 9/1,000 kcal); starch-based containing cereals and legumes (early agricultural diet); or Low-fat [contemporary therapeutic diet). All diets were intended to be weight-maintaining (mean intake, 2,577 kcal/d). Compared with the starch-based and low-fat diets, the high-fiber vegetable diet resulted in the largest reduction in low-density lipoprotein (LDL) cholesterol (33% +/- 4%, P < .001) and the greatest fecal bile acid output (1.13 0.30 g/d, P = .002), fecal bulk (906 +/- 130 g/d, P < .001), and fecal short-chain fatty acid outputs (78 13 mmol/d, P < .001). Nevertheless, due to the increase in fecal bulk, the actual concentrations of fecal bile acids were lowest on the vegetable diet (1.2 mg/g wet weight, P = .002). Maximum lipid reductions occurred within 1 week. Urinary mevalonic acid excretion increased (P = .036) on the high-vegetable diet reflecting large fecal steroid tosses. We conclude that very high-vegetable fiber intakes reduce risk factors for cardiovascular disease and possibly colon cancer. Vegetable and fruit fibers therefore warrant further detailed investigation. Copyright 2001 by W.B. Saunders Company.