THE BLOOD-BRAIN BARRIER AND THE EXTRACELLULAR SPACE OF BRAIN
THE BLOOD-BRAIN BARRIER AND THE EXTRACELLULAR SPACE OF BRAIN
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DOI：
10.1113/jphysiol.1959.sp006330
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发表时间：
1959-01-01
影响因子：
5.5
通讯作者：
SPAZIANI, E
中科院分区：
文献类型：
--
作者：
DAVSON, H;SPAZIANI, E
作者提供的数据表明，碘化物、对氨基马尿酸盐和蔗糖等物质在注入血液时，与它们渗透到骨骼肌中相比，以几乎不可测量的速率渗透脑组织。然而，用分离的孵育的脑半球片，摄取在速率和量上与骨骼肌中的摄取相当。这些数据被解释为证明在脑组织中存在这些物质可以容易地扩散的空间。在体内实验中未能占据该空间表明存在从血管系统扩散的屏障。
The authors present data to demonstrate that substances such as iodide, p-aminohippurate and sucrose, when injected into the blood, penetrate brain tissue at barely measurable rates by contrast with their penetration into skeletal muscle. However, with isolated incubated pieces of brain hemisphere, the uptakes are comparable in rate and amount with those in skeletal muscle. The data are interpreted as proving that there is a space into which these substances can diffuse readily in brain tissue. Failure of this space to be occupied in experiments in vivo indicates the presence of a barrier to diffusion from the vascular system.