Acute administration of methylphenidate differentially affects cortical processing of emotional facial expressions in attention-deficit hyperactivity disorder children as studied by functional near-infrared spectroscopy
Acute administration of methylphenidate differentially affects cortical processing of emotional facial expressions in attention-deficit hyperactivity disorder children as studied by functional near-infrared spectroscopy
复制标题
DOI：
10.1117/1.nph.7.2.025003
复制
发表时间：
2020-04-01
期刊：
影响因子：
5.3
通讯作者：
Dan, Ippeita
中科院分区：
文献类型：
--
作者：
Kobayashi, Megumi;Ikeda, Takahiro;Dan, Ippeita
重要性：据报道，注意力缺陷多动障碍（ADHD）的儿童在识别愤怒而不是快乐的面部表情方面存在障碍，并且他们对面部表情的反应表现出非典型的皮层激活模式。然而，关于ADHD学龄儿童面部表情识别受损的神经机制以及急性药物治疗对其面部表情加工的影响知之甚少。目的：我们旨在研究哌甲酯（MPH）急性给药影响ADHD儿童面部表情加工的可能性。方法：我们在一项随机、双盲、安慰剂对照的研究中，通过观察MPH或安慰剂给药前和给药后1.5小时快乐和愤怒的面部表情，测量了ADHD儿童双侧颞枕区的血流动力学变化，交叉设计研究。结果：我们发现，无论药物治疗，快乐的表情诱导增加氧合血红蛋白（oxy-Hb）的反应，在右下枕区，但不是在上级颞区。对于愤怒的表情，氧合血红蛋白反应增加后MPH管理，但不是安慰剂管理后，在左枕下区，而没有显着激活前MPH管理。我们的研究结果表明：（1）注意缺陷多动障碍儿童持续使用右枕下区来处理快乐的表情;当ADHD儿童处理愤怒的表情时，给予MPH会增强左枕下区的皮质激活。(C)作者。由SPIE在知识共享署名4.0未移植许可下发布。
Significance: It has been reported that children with attention-deficit hyperactivity disorder (ADHD) have impairment in the recognition of angry but not of happy facial expressions, and they show atypical cortical activation patterns in response to facial expressions. However, little is known about neural mechanisms underlying the impaired recognition of facial expressions in school-aged children with ADHD and the effects of acute medication on their processing of facial expressions.Aim: We aimed to investigate the possibility that acute administration of methylphenidate (MPH) affects processing of facial expressions in ADHD children.Approach: We measured the hemodynamic changes in the bilateral temporo-occipital areas of ADHD children observing the happy and angry facial expressions before and 1.5 h after MPH or placebo administration in a randomized, double-blind, placebo-controlled, crossover design study.Results: We found that, regardless of medication, happy expressions induced increased oxyhemoglobin (oxy-Hb) responses in the right inferior occipital region but not in the superior temporal region. For angry expressions, oxy-Hb responses increased after MPH administration, but not after placebo administration, in the left inferior occipital area, whereas there was no significant activation before MPH administration.Conclusions: Our results suggest that (1) ADHD children consistently recruit the right inferior occipital regions to process happy expressions and (2) MPH administration to ADHD children enhances cortical activation in the left inferior occipital regions when they process angry expressions. (C) The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License.