A Robust Fabrication Technique for Hydrogel Films Containing Micropatterned Opal Structures via Micromolding and an Integrated Evaporative Deposition-Photopolymerization Approach
A Robust Fabrication Technique for Hydrogel Films Containing Micropatterned Opal Structures via Micromolding and an Integrated Evaporative Deposition-Photopolymerization Approach
复制标题
DOI：
10.1021/acs.langmuir.0c02983
复制
发表时间：
2021-01-19
期刊：
影响因子：
3.9
通讯作者：
Yi, Hyunmin
中科院分区：
文献类型：
--
作者：
Bukenya, Maurice;Lee, Jun Hyuk;Yi, Hyunmin
具有微图案的蛋白石结构的薄膜水凝胶材料在广泛的传感应用中具有巨大的潜力。微图案化提供了关键的优势，如容易寻址，高通量测定和多路复用。然而，以快速、廉价和可靠的方式受控地制造这种膜仍然是一个挑战。现有技术的缺点是蛋白石沉积时间长，并且通常涉及复杂和艰巨的步骤。在这份报告中，我们研究了一个简单的微成型为基础的蒸发聚合方法，用于制造聚（乙二醇）为基础的水凝胶薄膜含有微图案蛋白石结构。具体地，通过在图案化微模具中蒸发沉积聚苯乙烯珠溶液来实现强烈且均匀的乳白色。这些蛋白石的微图案，然后捕获在水凝胶膜通过简单的光聚合的UV-可固化的PEG二丙烯酸酯溶液。所制备的薄膜显示出高的可调性以及对各种环境线索的响应性，这些环境线索容易通过颜色的变化表现出来。结合紫外-可见反射光谱和扫描电子显微镜的结果，这些发现说明了强大的，简单的，可靠的性质，我们的集成沉积聚合方法的光学活性和刺激响应功能材料的控制制造。因此，我们设想，这里报告的结果和简便的方法可以扩展到许多应用领域，包括环境监测，诊断和生物传感应用。
Opal-structured thin-film hydrogel materials with micropatterns hold great potential for utility in a wide range of sensing applications. Micropatterning offers key advantages such as ready addressability, high throughput assay, and multiplexing. However, controlled fabrication of such films in a rapid, inexpensive, and reliable manner remains a challenge. Existing techniques suffer from long opal deposition times and often involve complex and arduous steps. In this report, we examined a simple micromolding-based evaporation-polymerization method for the fabrication of poly(ethylene glycol)-based hydrogel films containing micropatterned opal structures. Specifically, intense and uniform opalescent colors were achieved by evaporative deposition of polystyrene bead solution in patterned micromolds. These opal micropatterns were then captured in hydrogel films by simple photopolymerization of a UV-curable PEG diacrylate solution. The as-prepared films show high tunability as well as responsiveness to various environmental cues readily manifested via shifts in color. Combined with UV-vis reflectance spectroscopy and scanning electron microscopy results, these findings illustrate the robust, simple, and reliable nature of our integrated deposition-polymerization approach for controlled fabrication of optically active and stimuli-responsive functional materials. We thus envision that the results and the facile approach reported here can be extended to many application areas including environmental monitoring, diagnostics, and biosensing applications.