Role of periostin and its antagonist PNDA-3 in gastric cancer metastasis
Role of periostin and its antagonist PNDA-3 in gastric cancer metastasis
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Periostin及其拮抗剂PNDA-3在胃癌转移中的作用
DOI：
10.3748/wjg.v21.i9.2605
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发表时间：
2015-03-07
影响因子：
4.3
通讯作者：
Wei, Bo
中科院分区：
文献类型：
--
作者：
Liu, Guo-Xiao;Xi, Hong-Qing;Wei, Bo
细胞外基质成分骨膜蛋白是一种分泌性蛋白质，其作为细胞附着蛋白和通过细胞粘附分子整合素α v β（3）和α v β（5）发出信号的自分泌或旁分泌因子发挥作用。Periostin参与心脏发育等正常生理活动，但也参与血管疾病、伤口修复、骨形成和肿瘤发育的病理生理过程。它在肿瘤生物学中越来越受到关注，因为它经常在各种上皮癌中过表达，并且在功能上参与转移进展的多个步骤。这些包括干细胞的维持、小生境的形成、EMT、肿瘤细胞的存活和血管生成，所有这些都是胃癌转移不可或缺的。已报道骨膜蛋白激活PI-3 K/AKT、Wnt和FAK介导的信号传导途径以促进转移。因此，骨膜蛋白代表了抑制转移的潜在有希望的候选物。在这篇综述文章中，我们总结了最新进展的知识骨膜蛋白，它的拮抗剂PNDA-3，和他们的影响等关键过程中的癌症转移，维持干细胞，生态位形成，上皮间质转化，肿瘤细胞存活和血管生成。特别是，我们把注意力集中在骨膜蛋白在胃癌转移中的作用，推测骨膜蛋白作为胃癌转移的治疗和诊断靶点的有用性，并考虑未来研究的潜在途径。
The extracellular matrix component periostin is a secreted protein that functions as both a cell attachment protein and an autocrine or paracrine factor that signals through the cell adhesion molecule integrins alpha v beta(3) and alpha v beta(5). Periostin participates in normal physiological activities such as cardiac development, but is also involved in pathophysiological processes in vascular diseases, wound repair, bone formation, and tumor development. It is of increasing interest in tumor biology because it is frequently overexpressed in a variety of epithelial carcinomas and is functionally involved in multiple steps of metastasis progression. These include the maintenance of stemness, niche formation, EMT, the survival of tumor cells, and angiogenesis, all of which are indispensable for gastric cancer metastasis. Periostin has been reported to activate the PI-3K/AKT, Wnt, and FAK-mediated signaling pathways to promote metastasis. Therefore, periostin represents a potentially promising candidate for the inhibition of metastasis. In this review article, we summarize recent advances in knowledge concerning periostin, its antagonist PNDA-3, and their influence on such key processes in cancer metastasis as maintenance of stemness, niche formation, epithelial-to-mesenchymal transition, tumor cell survival, and angiogenesis. In particular, we focus our attention on the role of periostin in gastric cancer metastasis, speculate as to the usefulness of periostin as a therapeutic and diagnostic target for gastric cancer metastasis, and consider potential avenues for future research.