NEURAL-TUBE DEFECTS AND 1ST TRIMESTER OPERATIONS
NEURAL-TUBE DEFECTS AND 1ST TRIMESTER OPERATIONS
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DOI：
10.1002/tera.1420410608
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发表时间：
1990-06-01
期刊：
影响因子：
--
通讯作者：
MAZZE, RI
中科院分区：
文献类型：
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作者：
KALLEN, B;MAZZE, RI
瑞典医疗保健登记处被用来识别在怀孕期间接受手术的妇女及其后代。在1973-1981年期间接受过早期妊娠手术的妇女所生的2,252名婴儿中，有6名婴儿被明确诊断为神经管缺陷（预期人数为2.5）。对记录的仔细检查显示，在妊娠4-5周（神经管形成期）发生了572次手术，6名神经管缺陷婴儿中有5名的母亲在此期间接受了手术（预期神经管缺陷数量为0.6），尽管其中一名后代可能患有Meckel综合征。本文讨论了神经管畸形与妊娠期手术的关系，并讨论了这种关系可能是随机的。
Swedish health care registries were used to identify women who had surgery during pregnancy and their offspring. Among the 2,252 infants born to women who had first trimester operations during 1973-1981, six had definite diagnoses of neural tube defects (expected number, 2.5). Scrutiny of the records showed that 572 operations occurred during gestational weeks 4-5, the period of neural tube formation, and that the mothers of five of the six infants with neural tube defects had an operation during the period (expected number of neural tube defects, 0.6) although one of the offspring probably had Meckel''s syndrome. The relationship between neural tube defects and operation during pregnancy is discussed including the possibility that the association may be random.