Liver fat content measured by magnetic resonance spectroscopy at 3.0 Tesla independently correlates with plasminogen activator inhibitor-1 and body mass index in type 2 diabetic subjects
Liver fat content measured by magnetic resonance spectroscopy at 3.0 Tesla independently correlates with plasminogen activator inhibitor-1 and body mass index in type 2 diabetic subjects
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DOI：
10.1620/tjem.206.23
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发表时间：
2005-05-01
影响因子：
2.2
通讯作者：
Satoh, J
中科院分区：
文献类型：
--
作者：
Ishii, M;Yoshioka, Y;Satoh, J
应用3-TESLA磁共振波谱(3-TESLA)对34例日本2型糖尿病患者的肝脏脂肪含量进行了测定，并分析了口服降糖药、胰岛素或降脂药物治疗后的肝脏脂肪含量与体成分和血浆代谢物的关系。肝脏脂肪含量与肥胖(体重指数[BMI]、体重、脂肪质量、腰臀比、内脏脂肪面积、皮下脂肪面积和血清甘油三酯)、胰岛素抵抗(空腹血浆胰岛素和胰岛素抵抗稳态模型评估[HOMA-IR])、脂肪细胞因子(血清纤溶酶原激活物抑制物-1[PAI-1]和瘦素)和血清胆碱酯酶显著相关，但CT肝/脾比率仅与空腹血糖、BMI和HOMA-IR相关。多元回归分析显示，肝脏脂肪含量与血清纤溶酶原激活物-1水平(p<；0.001)和体重指数(p<；0.05)独立相关，但与内脏脂肪面积无关。在无临床脂肪肝的2型糖尿病患者中，MRS是一种比CT更敏感的量化肝脏脂肪含量的方法。(C)2005年东北大学医科出版社。
We measured liver fat content by 3-Tesla magnetic resonance spectroscopy (MRS) in 34 non- to mild obese Japanese subjects with type 2 diabetes, who were riot complicated with any liver diseases including clinical fatty liver (liver/spleen ratio of cornputed tomography [CT] < 0.9) and were riot being treated with oral hypoglycemic agents, insulin, or lipid-lowering agents, and analyzed the relation-ship between liver fat content and body composition and plasma metabolite. The liver fat content is significantly correlated with variables relating to obesity (body mass index [BMI], body weight, fat mass, waist to hip ratio, visceral fat area, subcutaneous fat area, and serum triglyceride), insulin resistance (fasting plasma insulin and homeostasis model assessment Of insulin resistance [HOMA-IR]), adipocytokines (serum plasminogen activator inhibitor-1 [PAI-1] and leptin), and serum cholinesterase, but riot CT liver/spleen ratio, which is correlated only with fasting plasma glucose, BMI, and HOMA-IR. Multiple regression analysis revealed that the liver fat content is independently associated with serum PAI-1 level (p < 0.001) and BMI (p < 0.05), but riot visceral fat area. MRS is a more sensitive method for quantifying liver fat content than CT in type 2 diabetic subjects with non-to mild obesity and without clinical fatty liver. (c) 2005 Tohoku University Medical Press.