Immunocompromised and immunocompetent mouse models for head and neck squamous cell carcinoma.
Immunocompromised and immunocompetent mouse models for head and neck squamous cell carcinoma.
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头颈鳞状细胞癌的免疫功能低下和免疫能力的小鼠模型。
DOI：
10.2147/ott.s95633
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发表时间：
2016
影响因子：
4
通讯作者：
Tang YL
中科院分区：
文献类型：
--
作者：
Lei ZG;Ren XH;Wang SS;Liang XH;Tang YL
小鼠模型可以紧密模拟人类口腔鳞状上皮癌变过程，极大地拓展了体内研究的可能性，在头颈鳞状细胞癌的诊断、监测和治疗发展中发挥着关键作用。随着近年来免疫/炎症对癌症发生和进展的影响研究的进展，小鼠模型已分为两类，即免疫功能低下和免疫功能正常的小鼠模型。因此，本文将对这两种模型在头颈部鳞状细胞癌中的应用进行综述，为理解口腔鳞状上皮肿瘤发生过程中复杂的组织学、分子和遗传学变化提供一个平台。
Mouse models can closely mimic human oral squamous epithelial carcinogenesis, greatly expand the in vivo research possibilities, and play a critical role in the development of diagnosis, monitoring, and treatment of head and neck squamous cell carcinoma. With the development of the recent research on the contribution of immunity/inflammation to cancer initiation and progression, mouse models have been divided into two categories, namely, immunocompromised and immunocompetent mouse models. And thus, this paper will review these two kinds of models applied in head and neck squamous cell carcinoma to provide a platform to understand the complicated histological, molecular, and genetic changes of oral squamous epithelial tumorigenesis.