Fluctuating and sensory-induced vasodynamics in rodent cortex extend arteriole capacity
Fluctuating and sensory-induced vasodynamics in rodent cortex extend arteriole capacity
复制标题
DOI：
10.1073/pnas.1100428108
复制
发表时间：
2011-05-17
影响因子：
11.1
通讯作者：
Kleinfeld, David
中科院分区：
文献类型：
--
作者：
Drew, Patrick J.;Shih, Andy Y.;Kleinfeld, David
脑中的神经活动之后是血流量和血容量的局部变化。我们解决了清醒的，头部固定的小鼠的初级触须皮质内的小动脉与静脉血的相对体积变化。双光子激光扫描显微镜用于测量自发和感觉诱发的单血管水平的流量和容量的变化。我们发现小动脉表现出缓慢的（
Neural activity in the brain is followed by localized changes in blood flow and volume. We address the relative change in volume for arteriole vs. venous blood within primary vibrissa cortex of awake, head-fixed mice. Two-photon laser-scanning microscopywas used to measure spontaneous and sensory evoked changes in flow and volume at the level of single vessels. We find that arterioles exhibit slow (