IBD in children: lessons for adults.
IBD in children: lessons for adults.
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DOI：
10.1007/s11894-007-0070-8
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发表时间：
2007-12-01
影响因子：
--
通讯作者：
Markowitz, James
中科院分区：
文献类型：
--
作者：
Haller, Cindy A;Markowitz, James
当儿童患上炎症性肠病（IBD）时，医生和研究人员有机会在最早阶段了解这些慢性特发性疾病的性质。遗传易感性因素往往是常见的，而复杂的环境因素，如吸烟，通常不是一个问题。与成人患者的情况相反，克罗恩病通常在疾病的早期炎症阶段被诊断为儿童。小儿溃疡性结肠炎往往比成人更严重和更广泛的参与。在这两种形式的IBD中，疾病活动的严重程度通常决定了需要早期积极的营养，免疫调节和生物治疗。因此，从IBD儿童的评估和治疗中吸取的经验教训对临床医生照顾患有相同疾病的成人至关重要。
When children develop inflammatory bowel disease (IBD), physicians and researchers are presented with a singular opportunity to understand the nature of these chronic, idiopathic illnesses in the earliest stages. Genetic susceptibility factors tend to be common, whereas complicating environmental factors such as cigarette smoking are generally not an issue. As opposed to the case in adult patients, Crohn's disease is usually diagnosed in children at an early, inflammatory phase of the disease. Pediatric ulcerative colitis tends to present with more severe and more extensive involvement than in adults. In both forms of IBD, the severity of disease activity often dictates the need for early aggressive nutritional, immunomodulatory, and biologic therapy. As a result, the lessons learned from the evaluation and treatment of children with IBD are critically important to the clinician caring for adults with the same disorders.