Circadian variation of thyrotropin in childhood.
Circadian variation of thyrotropin in childhood.
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儿童时期促甲状腺素的昼夜变化。
DOI：
10.1210/jcem-68-6-1086
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
B. C. Nisula
中科院分区：
文献类型：
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作者：
Susan R. Rose;B. C. Nisula
本文观察了96例5~18岁正常儿童血清TSH的昼夜变化。每小时采血一次，连续24小时，用放射免疫法测定血清TSH，灵敏度为0.2mU/L，批内变异系数为4.9%。血清TSH峰值出现在2100~0600h，平均为1.6+/-0.1mU/L，平均峰值为3.7+/-0.2mU/L。夜间TSH峰值(TSH从最低点到峰值的百分比)为144%(95%可信限，50~300%)，与血清T4、游离T4、TSH、TH值、TH值或T3浓度。76名儿童给予TRH(7微克/公斤)。TRH后血清TSH峰值平均值为16.0+/-1.1mU/L(95%可信限为9.0~42.0mU/L)，92%的患儿TSH峰值出现在TRH后30min。夜间血清TSH绝对值与促甲状腺激素释放激素后峰值显著相关(r=0.62P<0.001)，而年龄、性别、青春期状况与夜间促甲状腺激素峰值及促甲状腺激素反应均无相关性。结论：正常儿童血清TSH昼夜节律变化以夜间TSH峰值为特征，夜间TSH峰值与TRH治疗后血清TSH峰值相关。
We evaluated the circadian variation of serum TSH in 96 normal children, aged 5-18 yr. Blood samples were obtained hourly for 24 h, and serum TSH was measured using an immunoradiometric assay with a sensitivity of 0.2 mU/L and an intraassay coefficient of variation of 4.9%. The nadir serum TSH value, defined by the three consecutive hourly TSH concentrations having the lowest mean, occurred between 1000 and 1900 h, while the peak TSH value, defined by the three consecutive hourly TSH concentrations having the greatest mean, occurred between 2100 and 0600 h. The mean nadir serum TSH was 1.6 +/- 0.1 mU/L, and the mean peak TSH was 3.7 +/- 0.2 mU/L. The mean nocturnal TSH surge (percent increase in TSH from nadir to peak) was 144% (95% confidence limits, 50-300%) and did not correlate with serum T4, free T4, or T3 concentrations. Seventy-six children were given TRH (7 micrograms/kg). The mean peak serum TSH after TRH was 16.0 +/- 1.1 mU/L (95% confidence limits, 9.0-42.0 mU/L), and it occurred by 30 min after TRH administration in 92% of the children. The absolute peak nocturnal serum TSH and peak post-TRH serum TSH values correlated significantly (r = 0.62; P less than 0.001), while age, gender, and pubertal status did not correlate with either the nocturnal TSH surge or the TSH response to TRH. We conclude that normal children have a circadian variation of serum TSH characterized by a nocturnal TSH surge, and that the peak of serum TSH, which occurs at night, correlates with the peak serum TSH level after TRH administration.