Fucoxanthin and Its Metabolite Fucoxanthinol in Cancer Prevention and Treatment.
Fucoxanthin and Its Metabolite Fucoxanthinol in Cancer Prevention and Treatment.
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DOI：
10.3390/md13084784
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发表时间：
2015-07-31
期刊：
影响因子：
5.4
通讯作者：
Martin LJ
中科院分区：
文献类型：
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作者：
Martin LJ
岩藻黄质是存在于褐色海藻的叶绿体中的类胡萝卜素。摄入后，主要通过胃肠道消化酶代谢为岩藻黄醇。这些化合物已被证明具有许多有益的健康效果，包括抗诱变、抗糖尿病、抗肥胖、抗炎和抗肿瘤作用。在每一种测试的癌症中，岩藻黄素醇对存活率、细胞周期停滞、细胞凋亡和NF-κB通路成员的调节作用比岩藻黄素更明显。岩藻黄质和岩藻黄醇的抗增殖和癌症预防作用是通过不同的信号传导途径介导的，包括半胱天冬酶、Bcl-2蛋白、MAPK、PI 3 K/Akt、JAK/STAT、AP-1、GADD 45和参与细胞周期停滞、细胞凋亡、抗血管生成或抑制转移的几种其他分子。本文就岩藻黄素和岩藻黄素醇在不同类型癌症中的作用机制作一综述。目前的研究结果表明，这些化合物可以有效地治疗和/或预防癌症的发展和侵袭性。
Fucoxanthin is a carotenoid present in the chloroplasts of brown seaweeds. When ingested, it is metabolized mainly to fucoxanthinol by digestive enzymes of the gastrointestinal tract. These compounds have been shown to have many beneficial health effects, including anti-mutagenic, anti-diabetic, anti-obesity, anti-inflammatory and anti-neoplastic actions. In every cancer tested, modulatory actions of fucoxanthinol on viability, cell-cycle arrest, apoptosis and members of the NF-κB pathway were more pronounced than that of fucoxanthin. Anti-proliferative and cancer preventing influences of fucoxanthin and fucoxanthinol are mediated through different signalling pathways, including the caspases, Bcl-2 proteins, MAPK, PI3K/Akt, JAK/STAT, AP-1, GADD45, and several other molecules that are involved in cell cycle arrest, apoptosis, anti-angiogenesis or inhibition of metastasis. In this review, we address the mechanisms of action of fucoxanthin and fucoxanthinol according to different types of cancers. Current findings suggest that these compounds could be effective for treatment and/or prevention of cancer development and aggressiveness.