Cancer cell metabolism and the modulating effects of nitric oxide.
Cancer cell metabolism and the modulating effects of nitric oxide.
复制标题
癌细胞代谢和一氧化氮的调节作用。
DOI：
10.1016/j.freeradbiomed.2014.11.012
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发表时间：
2015-02
影响因子：
7.4
通讯作者：
Hogg N
中科院分区：
文献类型：
--
作者：
Chang CF;Diers AR;Hogg N
多年来，代谢表型改变已被认为是肿瘤细胞的标志，但近年来，癌症表型的这一方面已成为更多关注的焦点。NOS2（诱导型一氧化氮合酶）已被认为是许多侵袭性肿瘤表型的组分，包括黑素瘤、胶质母细胞瘤和乳腺癌。一氧化氮已被公认为细胞生物能量学途径的调节剂，在许多方面类似于在侵袭性肿瘤中观察到的细胞代谢的改变。在这篇综述中，我们试图将这些概念与一般假设，即NOS2和NO在癌症中的功能之一是调节代谢过程，以促进肿瘤的侵略性增加。有许多机制，NO可以调节肿瘤代谢，包括直接抑制呼吸，线粒体质量的改变，生物能酶的氧化抑制，和二级信号通路的刺激。在这里，我们回顾代谢改变的背景下，癌细胞和讨论的作用，NO作为一个潜在的介质，这些变化。
Altered metabolic phenotype has been recognized as a hallmark of tumor cells for many years, but this aspect of the cancer phenotype has come into greater focus in recent years. NOS2 (inducible nitric oxide synthase of iNOS) has been implicated as a component in many aggressive tumor phenotypes, including melanoma, glioblastoma and breast cancer. Nitric oxide has been well established as a modulator of cellular bioenergetics pathways, in many ways similar to the alteration of cellular metabolism observed in aggressive tumors. In this review we attempt to bring these concepts together with the general hypothesis that one function of NOS2 and NO in cancer is to modulate metabolic processes to facilitate increased tumor aggression. There are many mechanisms by which NO can modulate tumor metabolism, including direct inhibition of respiration, alterations in mitochondrial mass, oxidative inhibition of bioenergetic enzymes, and the stimulation of secondary signaling pathways. Here we review metabolic alterations in the context of cancer cells and discuss the role of NO as a potential mediator of these changes.