Redox Status of β(2)GPI in Different Stages of Diabetic Angiopathy.
Redox Status of β(2)GPI in Different Stages of Diabetic Angiopathy.
复制标题
DOI：
10.1155/2016/8246839
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Yu P
中科院分区：
文献类型：
--
作者：
Ma J;Zhang JY;Liu Y;Yu DM;Yu P
探讨β 2糖蛋白I（β 2GPI）在糖尿病血管病变不同阶段的氧化还原状态。与健康对照组相比，2型糖尿病（T2DM）患者β 2GPI降低的比例显著降低（p < 0.05）。轻度冠状动脉粥样硬化性心脏病（CAD）患者β 2GPI降低的比例有高于非CAD组和重度CAD组的趋势，但无显著性差异（p > 0.05）。轻度A狭窄组和轻度糖尿病视网膜病变（DR）组β 2GPI降低的比例高于严重病变组。神经传导速度（Nerve Conduction Velocity，NCVS）轻慢组β 2GPI降低的比例高于Nerve Conduction Velocity正常组（Nerve Conduction Velocity，NCVN）和重度NCVS组。β 2GPI降低比例与24 h尿微量白蛋白、尿总蛋白呈正相关，与血清和皮肤晚期糖基化终末产物（AGEs）呈负相关。结果提示，β 2GPI在血管病变早期降低的比例增加，随着病变的加重而降低。
We explored the redox status of beta 2 glycoprotein I (β 2GPI) in different stages of diabetic angiopathy. Type 2 diabetes mellitus (T2DM) had a significantly lower proportion of reduced β 2GPI as compared to healthy controls (p < 0.05). There was a trend that the mild coronal atherosclerosis heart disease (CAD) had higher proportion of reduced β 2GPI than non-CAD and severe-CAD groups, however without significances (p > 0.05). The mild-A-stenosis group and mild-diabetic retinopathy (DR) groups had higher proportion of reduced β 2GPI than their severely affected counterparts. The mild-slow nerve conduction velocity (NCVS) group had higher proportion of reduced β 2GPI than normal nerve conduction velocity (NCVN group) and severe-NCVS groups. The proportion of reduced β 2GPI was in positive correlation with 24 h urine microalbumin and total urine protein, and the proportion of reduced β 2GPI was in negative correlation with serum and skin advanced glycation end products (AGEs). Taken together, our data implicate that the proportion of reduced β 2GPI increased in the early stage of angiopathy and decreased with the aggravation of angiopathy.
登录
查看更多内容
DOI：
10.1111/j.1365-2362.1992.tb01494.x
发表时间：
1992-07-01
影响因子：
5.5
作者：
VLACHOYIANNOPOULOS, PG;KRILIS, SA;MOUTSOPOULOS, HM
通讯作者：
MOUTSOPOULOS, HM
影响因子：
4.5
作者：
Zhang, Rui;Zhou, Sai-Jun;Yu, Pei
通讯作者：
Yu, Pei
影响因子：
20.3
作者：
Ioannou, Yiannis;Zhang, Jing-Yun;Krilis, Steven A.
通讯作者：
Krilis, Steven A.
还原的 β2-糖蛋白 I 可保护巨噬细胞免受 ox-LDL 诱导的泡沫细胞形成和细胞凋亡的影响。
影响因子：
4.5
作者：
Wang WL;Meng ZX;Zhou SJ;Li CJ;Chen R;Lv L;Ma ZJ;Yu DM;Yu P
通讯作者：
Yu P
影响因子：
6.5
作者：
Du, Vivian X.;van Os, Gwen;de Laat, Bas
通讯作者：
de Laat, Bas