Protein disulfide isomerases - a way to tackle malaria.

Protein disulfide isomerases - a way to tackle malaria.
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DOI:
10.1016/j.pt.2023.05.007
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发表时间:
2023-06
影响因子:
9.6
通讯作者:
F. Angrisano;Amelia Ford;A. Blagborough;H. Bullen
F. Angrisano;Amelia Ford;A. Blagborough;H. Bullen
中科院分区:
医学1区
文献类型:
--
作者:
F. Angrisano;Amelia Ford;A. Blagborough;H. Bullen

文献摘要

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蛋白质二硫键异构酶(PDI)确保特定底物蛋白质正确折叠。PDI活动在疟疾传播中起着至关重要的作用。在这里,我们概述了PDI在导致疟疾的疟原虫中的作用,并概述了为什么PDI抑制可能是治疗疟疾和防止传播的一种新方法。
Protein disulfide isomerases (PDIs) ensure that specific substrate proteins are correctly folded. PDI activity plays an essential role in malaria transmission. Here we provide an overview of the role of PDIs in malaria-causingPlasmodiumparasites and outline why PDI inhibition could be a novel way to treat malaria and prevent transmission.