Dynamics of structural and functional changes in hepatocyte mitochondria of senescence-accelerated OXYS rats
Dynamics of structural and functional changes in hepatocyte mitochondria of senescence-accelerated OXYS rats
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DOI：
10.1023/a:1013014919721
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发表时间：
2001-08-01
影响因子：
0.7
通讯作者：
Shalubueva, NI
中科院分区：
文献类型：
--
作者：
Kolosova, NG;Aidagulova, SV;Shalubueva, NI
电子显微镜显示，与 Wistar 大鼠相比，衰老加速的 OXYS 大鼠肝细胞出现退行性营养不良变化和线粒体结构失代偿。在 OXYS 大鼠肝线粒体功能障碍的情况下检测到这些迹象：所有代谢状态下的耗氧率降低、呼吸控制量、ADP/O 比率。跨膜电位和磷酸化率。线粒体结构和功能的紊乱是 OXYS 大鼠加速衰老和这些动物特有的内脏病变发病机制的关键因素。
Electron microscopy showed signs of degenerative dystrophic changes in hepatocytes and structural decompensation of mitochondria in senescence-accelerated OXYS rats in comparison with Wistar rats. These signs were detected in the presence of liver mitochondria dysfunction in OXYS rats: reduced oxygen consumption rate in all metabolic states, respiratory control volume, ADP/O ratio. transmembrane potential, and phosphorylation rate. The revealed disorders in mitochondrial structure and function are the key factors in the pathogenesis of accelerated aging in OXYS rats and visceropathies characteristic of these animals.