The relationship between entomological indicators of Aedes aegypti abundance and dengue virus infection.
The relationship between entomological indicators of Aedes aegypti abundance and dengue virus infection.
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DOI：
10.1371/journal.pntd.0005429
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发表时间：
2017-03
影响因子：
3.8
通讯作者：
Scott TW
中科院分区：
文献类型：
--
作者：
Cromwell EA;Stoddard ST;Barker CM;Van Rie A;Messer WB;Meshnick SR;Morrison AC;Scott TW
常规昆虫学监测数据被用来量化的丰度。埃及人。这些指标的公共卫生效用是基于这样的假设，即蚊子数量增加会增加人类登革病毒传播的风险，因此减少对媒介的暴露会降低感染率。分析了来自秘鲁伊基托斯的两项纵向队列研究的昆虫学调查数据，这些数据与间隔约6个月采集的8，153份配对血清学样本相关。Ae的指标埃及伊蚊密度计算的横截面和纵向昆虫学数据收集了超过12个月的幼虫，蛹和成人Ae。埃及人。对数二项模型用于估计风险比（RR），以衡量Ae。埃及人丰度和DENV血清转化的六个月风险。使用横截面昆虫学数据估计的RR进行了比较，估计使用纵向数据的RR。高横截面Ae.埃及人密度与DENV血清转化的风险增加无关。纵向昆虫学数据的使用导致RR范围从1.01（95%CI：1.01，1.02）到1.30（95%CI：1.17，1.46）成人阶段的密度估计和RR范围从1.21（95%CI：1.07，1.37）到1.75（95%CI：1.23，2.5）分类未成熟指数。AE.根据纵向昆虫学数据计算的埃及伊蚊密度与DENV血清转化相关，而横截面测量的密度则与DENV血清转化无关。AE.从横断面监测计算的埃及指标，如通常的做法，在检测DENV感染的高风险地区或人群中具有有限的公共卫生效用。在这项研究中，我们比较了通过常规家庭昆虫学监测收集的昆虫学风险措施，估计与人类登革病毒感染的关联。纵向昆虫学和人类血清学数据从伊基托斯，秘鲁，被用来测试之间的关联。埃及指数和6个月DENV血清转化的风险。我们的分析发现Ae的横截面测量值之间没有关联。埃及伊蚊丰度和登革病毒血清转化的风险。Ae的纵向测量。埃及伊蚊是登革病毒风险的更好代表，主要是在成年阶段的蚊子指标。登革病毒的传播是复杂的和随时间变化的;病媒密度和风险之间的关系不是静态的，也不是通过定期昆虫监测充分表征的。虽然昆虫学监测将继续在评估病媒控制干预措施方面发挥作用（例如，比较干预前和干预后的丰度），我们的分析对大多数Ae的有效性提出了挑战。埃及指标作为真实DENV暴露风险的适当代理。
Routine entomological monitoring data are used to quantify the abundance of Ae. aegypti. The public health utility of these indicators is based on the assumption that greater mosquito abundance increases the risk of human DENV transmission, and therefore reducing exposure to the vector decreases incidence of infection. Entomological survey data from two longitudinal cohort studies in Iquitos, Peru, linked with 8,153 paired serological samples taken approximately six months apart were analyzed. Indicators of Ae. aegypti density were calculated from cross-sectional and longitudinal entomological data collected over a 12-month period for larval, pupal and adult Ae. aegypti. Log binomial models were used to estimate risk ratios (RR) to measure the association between Ae. aegypti abundance and the six-month risk of DENV seroconversion. RRs estimated using cross-sectional entomological data were compared to RRs estimated using longitudinal data. Higher cross-sectional Ae. aegypti densities were not associated with an increased risk of DENV seroconversion. Use of longitudinal entomological data resulted in RRs ranging from 1.01 (95% CI: 1.01, 1.02) to 1.30 (95% CI: 1.17, 1.46) for adult stage density estimates and RRs ranging from 1.21 (95% CI: 1.07, 1.37) to 1.75 (95% CI: 1.23, 2.5) for categorical immature indices. Ae. aegypti densities calculated from longitudinal entomological data were associated with DENV seroconversion, whereas those measured cross-sectionally were not. Ae. aegypti indicators calculated from cross-sectional surveillance, as is common practice, have limited public health utility in detecting areas or populations at high risk of DENV infection. In this study, we compared measures of entomological risk collected through routine household entomological monitoring by estimating an association with human DENV infection. Longitudinal entomological and human serology data from Iquitos, Peru, were used to test associations between Ae. aegypti indices and the 6-month risk of DENV seroconversion. Our analysis found no association between cross-sectional measures of Ae. aegypti abundance and the risk of DENV seroconversion. Longitudinal measures of Ae. aegypti were better proxies for DENV risk, primarily among adult stage mosquito indicators. DENV transmission is complex and time-varying; the relationship between vector density and risk is not static nor adequately characterized through periodic entomological surveillance. While entomological monitoring will continue to serve a role in the evaluation of vector control interventions (e.g., comparing pre- and post-intervention abundance), our analysis challenges the validity of most Ae. aegypti indicators as adequate proxies for true DENV exposure risk.