Cross-talk between enteric pathogens and the intestine.
Cross-talk between enteric pathogens and the intestine.
复制标题
肠道病原体和肠道之间的串扰。
DOI：
10.1046/j.1462-5822.2000.00041.x
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Fasano,A
中科院分区：
文献类型：
--
作者：
Uzzau,S;Fasano,A
肠道病原体可以精细调节毒力基因的表达，以响应肠道环境产生的刺激。这篇小综述集中于最近发现的肠道细菌通过阐述与特定宿主对应物共享结构和功能的因子来引起肠道分泌的策略。这样的细菌抗原似乎在很大程度上干扰上皮细胞信号传导，该信号传导在生理学上调节许多并且尚未完全阐明的控制跨细胞和细胞旁分泌途径的机制。由产肠毒素大肠杆菌和肠聚集性大肠杆菌产生的热稳定肠毒素（ST）。大肠杆菌肠毒素（EAST 1）都是肠毒素的典型实例，其通过模拟鸟苷素（cGMP信号传导的内源性调节剂）来激活跨细胞分泌途径。沙门氏菌已经开发出替代策略，通过精心制作一种因子（SopB）来诱导肠道分泌，该因子类似于至少两种宿主细胞4-磷酸酶，激活Ca依赖性跨细胞分泌途径的酶。最后，霍乱弧菌开发了创新的策略，通过精心制作封闭带毒素（Zot），一种模拟最近描述的细胞间紧密连接的生理调节因子，激活细胞旁分泌途径。
Enteric pathogens finely regulate the expression of virulence genes in reply to stimuli generated by the intestinal environment. This minireview focuses on recently discovered strategies developed by enteric bacteria to cause intestinal secretion through the elaboration of factors that share structure and function with specific host counterparts. Such bacterial antigens appear to interfere largely with the epithelial cell signalling that physiologically regulates the numerous and, as yet not fully elucidated, mechanisms controlling both the transcellular and the paracellular secretion pathways. Heat‐stable enterotoxins (STs) elaborated by enterotoxigenicEscherichia coliand the enteroaggregativeE. colienterotoxin (EAST1) are both typical examples of enteric toxins that activate the transcellular secretion pathway by mimicking guanylin, the endogenous modulator of cGMP signalling. Alternative strategies have been developed bySalmonellato induce intestinal secretion through the elaboration of a factor (SopB) that resembles at least two of the host cell 4‐phosphatases, enzymes that activate the Ca‐dependent transcellular secretion pathway. Finally,Vibrio choleraehas developed innovative tactics to activate the paracellular secretion pathway through the elaboration of Zonula occludens toxin (Zot), a factor that mimics a recently described physiological modulator of intercellular tight junctions.