LOCALIZATION OF SUBCLINICAL ICTAL ACTIVITY BY FUNCTIONAL MAGNETIC-RESONANCE-IMAGING - CORRELATION WITH INVASIVE MONITORING
LOCALIZATION OF SUBCLINICAL ICTAL ACTIVITY BY FUNCTIONAL MAGNETIC-RESONANCE-IMAGING - CORRELATION WITH INVASIVE MONITORING
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DOI：
10.1002/ana.410380410
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发表时间：
1995-10-01
影响因子：
11.2
通讯作者：
FRENCH, JA
中科院分区：
文献类型：
--
作者：
DETRE, JA;SIRVEN, JI;FRENCH, JA
应用基于敏感度对比的功能磁共振成像(FMRI)检测了一例局灶性癫痫患者脑血流和代谢的局灶性变化。患者出现频繁的部分运动性癫痫，累及他的右下面部，并蔓延至语言障碍，偶尔还会出现右臂痉挛。在这些事件中，意识从未受到损害。采用多层回波平面成像技术，每4s连续采集16层轴位图像，时间为11min。虽然患者在扫描过程中没有观察到或报告明显的癫痫发作，但对功能数据的时间序列分析显示，左侧额叶后叶的局灶性信号强度变化，在持续时间和空间定位上与随后通过有创电生理监测记录的癫痫活动具有很好的相关性。在预测手术成功的部位方面，fMRI的空间定位比从硬膜下网格处记录的脑电更准确。这些结果说明了功能磁共振成像在高空间和高时间分辨率的癫痫灶定位方面的潜力。这样的研究可以很容易地与高分辨率解剖成像、任务激活研究和其他磁共振技术相结合。
Functional magnetic resonance imaging (fMRI) with susceptibility-based contrast was used to detect focal changes in cerebral blood flow and metabolism in a patient with focal epilepsy. The patient presented with frequent partial motor seizures involving his right lower face that spread to produce speech arrest and occasionally right arm jerking. Consciousness was never impaired during these events. A multislice echoplanar technique was used to acquire 16 contiguous axial slices every 4 seconds for 11 minutes. Although no overt seizures were observed or reported by the patient during the scanning, a time series analysis of the functional data revealed focal signal-intensity changes in the posterior left frontal lobe, which correlated well both in duration and spatial localization with ictal activity subsequently recorded by invasive electrophysiological monitoring. The spatial localization of fMRI was more accurate than electroencephalography recorded from a subdural grid in predicting the site of successful surgical therapy. These results illustrate the potential of functional MRI for localizing seizure foci with high spatial and temporal resolution. Such studies can be readily combined with high-resolution anatomical imaging, task-activation studies, and other magnetic resonance techniques.