Dopamine transporter availability in medication free and in bupropion treated depression:: A 99mTc-TRODAT-1 SPECT study
Dopamine transporter availability in medication free and in bupropion treated depression:: A 99mTc-TRODAT-1 SPECT study
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DOI：
10.1016/j.jad.2005.08.016
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发表时间：
2005-12-01
影响因子：
6.6
通讯作者：
Pávics, L
中科院分区：
文献类型：
--
作者：
Argyelán, M;Szabó, Z;Pávics, L
背景：安非他酮被认为是通过阻断多巴胺转运蛋白（DAT）发挥其抗抑郁作用。本研究采用~（99）Tc-TRODAT-1 SPECT显像技术对抑郁症患者的DAT活性进行了测定，并与安非他酮治疗的疗效进行了比较。结果：抑郁症患者的基线DAT纹状体-枕叶比值（SOR）（1.04 +/-.36，平均值+/- SD）与对照组（1.12 +/-.33）无显著差异（p >.05）。安非他酮治疗患者的基线SOR和HAM-D评分变化之间存在相关性（r =-0.745，p = 0.02）。安非他酮治疗的平均DAT占用率为20.84 +/-27.7%。治疗效果和占用率之间没有显着的相关性observed.Limitations：我们的研究的限制因素之一是缺乏药物monitoring.Conclusions：在良好的协议与其他PET研究，我们发现20.84%DAT占用安非他酮治疗期间。治疗效果和DAT占用率之间缺乏相关性，这可能会引发一个问题，即安非他酮的作用是否涉及其他机制。(c)2005 Elsevier B. V.保留所有权利。
Background: Bupropion is thought to exert its antidepressive effect by blocking the dopamine transporter (DAT). The purpose of this study was to evaluate the DAT activity in depressed patients by means of Tc-99m-TRODAT-1 SPECT in relation to the efficacy of bupropion treatment.Methods: In 12 healthy controls and 16 depressed patients the baseline DAT activity was examined. Nine of the 16 patients went through an additional second SPECT investigation, after 4 weeks of bupropion treatment.Results: In the depressed patients, the baseline DAT striatum-occipital ratio (SOR) (1.04 +/-.36, mean +/- SD) was not significantly different from that in the control group (1.12 +/-.33) (p >.05). Correlation was found between baseline SOR and HAM-D score change (r = - .745, p =.02) of the bupropion treated patients. The average DAT occupancy due to the bupropion treatment was 20.84 +/- 27.7%. No significant correlation between the therapeutical effectiveness and the occupancy was observed.Limitations: One of the limiting factors of our study has been the lack of drug monitoring.Conclusions: In good agreement with other PET studies, we found 20.84% DAT occupancy during bupropion treatment. The lack of correlation between the efficacy of therapy and occupancy of DAT may raise the question as to whether other mechanisms are involved in the effect of bupropion. (c) 2005 Elsevier B.V. All rights reserved.