Intrinsic and Extrinsic Determinants Linking Spindle Pole Fate, Spindle Polarity, and Asymmetric Cell Division in the Budding Yeast S-cerevisiae
Intrinsic and Extrinsic Determinants Linking Spindle Pole Fate, Spindle Polarity, and Asymmetric Cell Division in the Budding Yeast S-cerevisiae
复制标题
DOI：
10.1007/978-3-319-53150-2_3
复制
发表时间：
2017-01-01
期刊：
影响因子：
--
通讯作者：
Segal, Marisa
中科院分区：
文献类型：
--
作者：
Geymonat, Marco;Segal, Marisa
芽殖酵母S.酿酒酵母是理解驱动不对称细胞分裂的多层控制的强大模型。在芽殖酵母中，纺锤体极分别向母细胞和芽细胞隔室的不对称靶向使有丝分裂纺锤体沿着母芽轴定向。该程序利用了纺锤极之间的年龄差异所产生的内在功能不对称性--一个是从之前的分裂中继承的，另一个是新组装的。外在机制将这种年龄差异转化为不同的命运。该程序的执行将纺锤体定向与较老的纺锤体极到芽的分离相结合。值得注意的是，在自我更新的干细胞分裂中发生了类似的定型遗传模式，这强调了研究酵母中纺锤体极性和差异命运的普遍重要性。在这里，我们审查的机制占这一关键的内在和外在的不对称性之间的相互作用，翻译纺锤极年龄差异的命运。
The budding yeast S. cerevisiae is a powerful model to understand the multiple layers of control driving an asymmetric cell division. In budding yeast, asymmetric targeting of the spindle poles to the mother and bud cell compartments respectively orients the mitotic spindle along the mother-bud axis. This program exploits an intrinsic functional asymmetry arising from the age distinction between the spindle poles-one inherited from the preceding division and the other newly assembled. Extrinsic mechanisms convert this age distinction into differential fate. Execution of this program couples spindle orientation with the segregation of the older spindle pole to the bud. Remarkably, similar stereotyped patterns of inheritance occur in self-renewing stem cell divisions underscoring the general importance of studying spindle polarity and differential fate in yeast. Here, we review the mechanisms accounting for this pivotal interplay between intrinsic and extrinsic asymmetries that translate spindle pole age into differential fate.