Remembrance of odors past: Human olfactory cortex in cross-modal recognition memory
Remembrance of odors past: Human olfactory cortex in cross-modal recognition memory
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DOI：
10.1016/s0896-6273(04)00270-3
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发表时间：
2004-05-27
期刊：
影响因子：
16.2
通讯作者：
Dolan, RJ
中科院分区：
文献类型：
--
作者：
Gottfried, JA;Smith, APR;Dolan, RJ
情景记忆通常充满了多感官的丰富性，因此对事件的回忆可以被赋予其先前发生的景象，声音和气味。虽然海马和相关的内侧颞叶结构涉及情节记忆检索，参与的感觉特异性皮层代表的质量的情节是不太确定的。我们将功能性磁共振成像（fMRI）与跨模态范式相结合，在该范式中，在记忆编码过程中向对象呈现气味。然后，我们研究了气味背景对神经反应的影响，在检索时，这些相同的对象单独呈现。初级嗅觉（梨状）皮层，以及前海马，被激活，在成功检索旧（相比新）对象。我们的研究结果表明，原始记忆痕迹的感觉功能保留在单峰嗅觉皮层。我们认为，分布在特定模式的大脑区域的记忆痕迹的重新激活巩固了情景记忆的感官质量。
Episodic memory is often imbued with multisensory richness, such that the recall of an event can be endowed with the sights, sounds, and smells of its prior occurrence. While hippocampus and related medial temporal structures are implicated in episodic memory retrieval, the participation of sensory-specific cortex in representing the qualities of an episode is less well established. We combined functional magnetic resonance imaging (fMRI) with a cross-modal paradigm, where objects were presented with odors during memory encoding. We then examined the effect of odor context on neural responses at retrieval when these same objects were presented alone. Primary olfactory (piriform) cortex, as well as anterior hippocampus, was activated during the successful retrieval of old (compared to new) objects. Our findings indicate that sensory features of the original engram are preserved in unimodal olfactory cortex. We suggest that reactivation of memory traces distributed across modality-specific brain areas underpins the sensory qualities of episodic memories.