Hospital-based surveillance of enteric parasites in Kolkata.
Hospital-based surveillance of enteric parasites in Kolkata.
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DOI：
10.1186/1756-0500-2-110
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发表时间：
2009-06-19
影响因子：
1.8
通讯作者：
Ganguly S
中科院分区：
文献类型：
--
作者：
Mukherjee AK;Chowdhury P;Bhattacharya MK;Ghosh M;Rajendran K;Ganguly S
腹泻是发展中国家疾病和死亡的第二大原因，也是这些国家五岁以下儿童因传染病死亡的第二大常见原因。寄生虫以及细菌和病毒病原体是腹泻的重要原因。然而，寄生虫感染有时被忽视，导致一段时间后病因不明。在本文中，我们报告的流行贾第鞭毛虫，溶组织内阿米巴和隐孢子虫。在加尔各答及其周围地区。在2007年11月至2008年10月期间入住传染病（ID）医院（人群= 1103）的肠道投诉患者中进行了一项基于医院的实验室监测研究。在采集的1103份样本中，147份对蓝氏贾第鞭毛虫呈阳性，84份对隐孢子虫呈阳性，51份对溶组织内阿米巴呈阳性。对于所有这些寄生虫有很高的混合感染率与常见的肠道病毒和细菌，如轮状病毒，霍乱弧菌和志贺氏菌。也有合并感染的情况下，与所有其他致炎性病原体。≥ 5岁年龄组的寄生虫感染率最高，而>5 - 10岁年龄组的感染率以蓝氏贾第鞭毛虫为主（p =< 0.001;比值比（OR）= 3.937; 95%置信区间（CI）= 1.862 - 8.326）和所有寄生虫（p = 0.040; OR = 2.043; 95%CI = 1.033 - 4.039）。年龄组>10 - 20岁也可被认为是G. Lamblia（p = 0.009; OR = 2.231; 95%CI = 1.223 - 4.067）。月发生率数据显示，存在地方性G。Lamblia，隐孢子虫属（Cryptosporidium sp.）组织溶解症零星发生。地理信息系统的研究表明，寄生虫在坦格拉、蒂尔贾拉和拉贾哈特等主要是贫民窟的地区更为普遍。由于大多数被调查的人口属于低收入群体，饮用受污染的水和食物可能是寄生虫感染的主要根本原因。这项研究提供了重要的信息的发生和分布的三个重要的肠道寄生虫，并表明其在加尔各答和周边地区的寄生虫的能力。
Diarrhoea is the second leading cause of illness and death in developing countries and the second commonest cause of death due to infectious diseases among children under five in such countries. Parasites, as well as bacterial and viral pathogens, are important causes of diarrhoea. However, parasitic infections are sometimes overlooked, leading after a period of time to an uncertain aetiology. In this paper we report the prevalence of Giardia lamblia, Entamoeba histolytica and Cryptosporidium sp. in and around Kolkata. A hospital-based laboratory surveillance study was conducted among the patients admitted between November 2007 and October 2008 to the Infectious Diseases (ID) Hospital (Population = 1103) with diarrhoeal complaints. Of the 1103 samples collected, 147 were positive for Giardia lamblia, 84 for Cryptosporidium sp. and 51 for Entamoeba histolytica. For all these parasites there was a high rate of mixed infection with common enteric viruses and bacteria such as Rotavirus, Vibrio cholerae and Shigella sp. There were also cases of co-infection with all other diarrheogenic pathogens. The age group ≥ 5 years had the highest prevalence of parasites whereas the age group >5 – 10 years was predominantly infected with Giardia lamblia (p =< 0.001; Odds ratio (OR) = 3.937; 95% Confidence interval (CI) = 1.862 – 8.326) and with all parasites (p = 0.040; OR = 2.043; 95% CI = 1.033 – 4.039). The age group >10 – 20 years could also be considered at risk for G. lamblia (p = 0.009; OR = 2.231; 95% CI = 1.223 – 4.067). Month-wise occurrence data showed an endemic presence of G. lamblia whereas Cryptosporidium sp. and E. histolytica occurred sporadically. The GIS study revealed that parasites were more prevalent in areas such as Tangra, Tiljala and Rajarhat, which are mainly slum areas. Because most of the population surveyed was in the lower income group, consumption of contaminated water and food could be the major underlying cause of parasitic infestations. This study provides important information on the occurrence and distribution of three important intestinal parasites and indicates their diarrheogenic capacity in Kolkata and surrounding areas.