Models of inflammation: Carrageenan- or complete Freund's Adjuvant (CFA)-induced edema and hypersensitivity in the rat.
Models of inflammation: Carrageenan- or complete Freund's Adjuvant (CFA)-induced edema and hypersensitivity in the rat.
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DOI：
10.1002/0471141755.ph0504s56
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发表时间：
2012-03-01
影响因子：
--
通讯作者：
Duarte, Djane B
中科院分区：
文献类型：
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作者：
Fehrenbacher, Jill C;Vasko, Michael R;Duarte, Djane B
炎症动物模型用于评估炎症部位炎症介质的产生，非甾体抗炎药（NSAIDs）等药物的抗炎特性，以及推定的镇痛化合物在逆转皮肤过敏反应中的功效。本单元详细介绍了引发和测量卡拉胶和完全弗氏佐剂（CFA）诱导的皮肤炎症的方法。由于背根感觉系统和三叉神经感觉系统之间可能存在差异，本文描述了足垫或振动垫的注射。通过这种方式，可以在腰椎背根神经节神经元（足垫）和三叉神经节神经元（振动垫）支配的组织中评估皮肤炎症。
Animal models of inflammation are used to assess the production of inflammatory mediators at sites of inflammation, the anti-inflammatory properties of agents such as nonsteroidal anti-inflammatory drugs (NSAIDs), and the efficacy of putative analgesic compounds in reversing cutaneous hypersensitivity. This unit details methods to elicit and measure carrageenan- and complete Freund's adjuvant (CFA)-induced cutaneous inflammation. Due to possible differences between the dorsal root sensory system and the trigeminal sensory system, injections of either the footpad or vibrissal pad are described. In this manner, cutaneous inflammation can be assessed in tissue innervated by the lumbar dorsal root ganglion neurons (footpad) and by the trigeminal ganglion neurons (vibrissal pad).