Increased gonadotropin responsiveness to gonadotropin-releasing hormone during fasting in normal subjects.
Increased gonadotropin responsiveness to gonadotropin-releasing hormone during fasting in normal subjects.
复制标题
正常受试者禁食期间促性腺激素对促性腺激素释放激素的反应性增加。
DOI：
10.1016/0026-0495(87)90057-6
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
S. Röjdmark
中科院分区：
文献类型：
--
作者：
S. Röjdmark
为了研究食物剥夺是否影响垂体促性腺激素的释放，研究了12名健康受试者（6男6女）在禁食一夜和禁食56小时后静脉注射50 μg促性腺激素释放激素（GnRH）后黄体生成素（LH）和促卵泡激素（FSH）的反应。在女性参与者中，这些GnRH测试在月经周期的卵泡期早期进行。空腹期间血糖由4.4±0.1 （mean±SEM）降至3.3±0.1 mmol/L （P< 0.001）。LH和FSH对gnrh的响应性（通过激素增量面积反映）从1973±256增加到3267±450 (IU/L × min) (P< 0.001)， FSH从376±44增加到705±112 (IU/L × min) （P< 0.01）。当对照研究以与禁食参与者完全相同的方式在非禁食受试者中进行时，促性腺激素对GnRH的反应性在测试之间没有显着变化。为了探索禁食受试者中促性腺激素反应性增加的可能机制，上述6名健康女性在额外的56小时禁食期间给予9次小剂量口服葡萄糖（每次剂量0.5 g/kg），以防止血糖在食物剥夺期间显著下降。这根本没有改变激素反应模式，因为在补充葡萄糖的禁食期间，LH和FSH对GnRH的反应都显著增加。另外6名正常妇女口服甲氧氯普胺（MET），剂量为10毫克，每日3次，以诱导多巴胺（DA）受体在56小时的禁食中被阻断。该实验设计显示，空腹时LH和FSH对GnRH的反应持续增加。结果表明，短期禁食增加了正常受试者的促性腺激素对外源性GnRH的敏感性。禁食引起的葡萄糖输送到促性腺激素的减少可能不是上述禁食作用背后的机制。虽然中央DA活动的增加可能很重要，但其他未知因素也可能在这方面发挥突出作用。
To investigate whether food deprivation affects hormone release from pituitary gonadotrophs, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) responses to intravenous (IV) administration of 50 μg gonadotropin-releasing hormone (GnRH) were determined in 12 healthy subjects (six women and six men) after an overnight fast and after a fasting period of 56 hours. In the female participants, these GnRH tests were performed early in the follicular phase of the menstrual cycle. Blood glucose declined during the fast from 4.4 ± 0.1 (mean ± SEM) to 3.3 ± 0.1 mmol/L (P< .001). LH and FSH responsiveness to GnRH—as reflected by hormone incremental areas—increased from 1973 ± 256 to 3267 ± 450 (IU/L × min) for LH (P< .001), and from 376 ± 44 to 705 ± 112 (IU/L × min) for FSH (P< .01). When control studies were carried out in nonfasted subjects in exactly the same way as in the fasted participants, the gonadotropin responsiveness to GnRH did not change significantly between the tests. To explore possible mechanisms behind the increased gonadotropin responsiveness in fasted subjects, six of the above mentioned healthy women were given nine small oral doses of glucose (each dose 0.5 g/kg) during an additional 56-hour fast to prevent blood glucose from falling significantly during the period of food deprivation. This did not change the hormone response pattern at all, since both the LH and the FSH responses to GnRH increased significantly during the glucose-supplemented fasting period. Six additional normal women were given metoclopramide (MET) orally, at a dose of 10 mg three times daily, to induce dopamine (DA) receptor blockade during a 56-hour fast. This experimental design revealed LH and FSH responses to GnRH that were to longer increased in fasting. The results imply that short-term fasting increases the sensitivity of the gonadotrophs to exogenous GnRH in normal subjects. A fasting-induced decrease in the glucose delivery to the gonadotrophs is probably not the mechanism behind the above mentioned effect of fasting. Although an increased central DA activity may be of importance, other, as yet unknown factors, may also play prominent roles in this context.
下丘脑损伤大鼠中垂体促性腺激素释放激素 (GnRH) 受体对 GnRH 的反应：高催乳素血症对反应的抑制以及睾酮和雌二醇调节受体后位点促性腺激素分泌的证据。
影响因子：
4.8
作者：
Pieper,DR;Gala,RR;Schiff,MA;Regiani,SR;Marshall,JC
通讯作者：
Marshall,JC