Demonstration of a difference in urinary calcium, not calcium absorption, in black and white adolescents.
Demonstration of a difference in urinary calcium, not calcium absorption, in black and white adolescents.
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证明黑人和白人青少年尿钙存在差异，而不是钙吸收差异。
DOI：
10.1002/jbmr.5650080912
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Shary,JR
中科院分区：
文献类型：
--
作者：
Bell,NH;Yergey,AL;Vieira,NE;Oexmann,MJ;Shary,JR
黑人儿童前臂、腰椎和股骨颈的骨密度(BMD)高于白人儿童。研究的目的是确定黑人儿童肠道钙吸收和/或尿钙吸收的差异是否会导致更积极的钙平衡和更大的骨量。正常的黑人和白人男孩和女孩被送进代谢病房，每天给予含有1000毫克钙的持续饮食，其中60%为碳酸钙，为期2.5天(研究I)或3.5天(研究II)。采集空腹血和24小时尿液，并用稳定的钙同位素测定单向部分吸钙量(α)。结果发现：(1)黑人儿童血清25-羟基维生素D(25-OHD)和尿钙低于白人儿童，血清1，25-二羟基维生素D[1，25-(OH)2D]高于白人儿童；(2)黑人儿童α高于女孩，无种族差异；(3)黑人儿童、黑人儿童和白人儿童α与尿钙呈显著正相关。结论：(1)男性α高于女性；(2)黑人较低的尿钙，而不是增加的肠道钙吸收，是导致黑人骨密度种族差异的主要原因。
Bone mineral density (BMD) of the forearm, lumbar spine, and femoral neck is greater in black than in white children. Studies were performed to determine whether differences in intestinal absorption of calcium or urinary calcium or both account for an assumed more positive calcium balance and greater bone mass in black children. Normal black and white boys and girls were admitted to a metabolic ward and given a constant daily diet containing 1000 mg calcium, 60% as calcium carbonate, for 2½ days (study I) or 3½ days (study II). Fasting blood and 24 h urine collections were obtained, and in study II, unidirectional fractional absorption of calcium (α) was determined with stable isotopes of calcium. It was found that (1) serum 25‐hydroxyvitamin D (25‐OHD) and urinary calcium were lower and serum 1,25‐dihydroxyvitamin D [1,25‐(OH)2D] was higher in black than in white children, and (2) α was higher in boys than in girls with no racial difference, and (3) there were significant positive correlations between α and urinary calcium in the blacks and in the black and white children together. It is concluded that (1) α is higher in boys than in girls and (2) a lower urinary calcium, not increased intestinal absorption of calcium, is the means for a more positive calcium balance in blacks that accounts for the racial difference in BMD.