Deletion in chromosome 11p associated with a hepatitis B integration site in hepatocellular carcinoma.
Deletion in chromosome 11p associated with a hepatitis B integration site in hepatocellular carcinoma.
复制标题
与肝细胞癌中乙型肝炎整合位点相关的 11p 染色体缺失。
DOI：
10.1126/science.2996131
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Kew,M
中科院分区：
文献类型：
--
作者：
Rogler,CE;Sherman,M;Su,CY;Shafritz,DA;Summers,J;Shows,TB;Henderson,A;Kew,M
乙型肝炎病毒（HBV）是一种已知具有致癌潜力的病毒，在人类长期持续感染期间整合到细胞DNA中。从病毒载体分离的肝细胞癌通常含有克隆繁殖的病毒DNA整合体。由于小染色体缺失与几种类型的癌症相关，因此研究了肝细胞癌中与HBV整合相关的染色体缺失的发生。在人肝细胞癌中，HBV整合伴随着至少13.5千碱基的细胞序列缺失。病毒DNA整合和细胞序列缺失发生在11号染色体短臂11p13-11p14位置。在HBV整合位点被删除的细胞序列从肿瘤细胞中丢失，只留下一个剩余的细胞等位基因拷贝。
Hepatitis B virus (HBV), a virus with known carcinogenic potential, integrates into cellular DNA during long-term persistent infection in man. Hepatocellular carcinomas isolated from viral carriers often contain clonally propagated viral DNA integrations. As small chromosomal deletions are associated with several types of carcinomas, the occurrence of chromosomal deletions in association with HBV integration in hepatocellular carcinoma was studied. HBV integration was accompanied by a deletion of at least 13.5 kilobases of cellular sequences in a human hepatocellular carcinoma. The viral DNA integration and deletion of cellular sequences occurred on the short arm of chromosome 11 at location 11p13-11p14. The cellular sequences that were deleted at the site of HBV integration were lost from the tumor cells, leaving only a single copy of the remaining cellular allele.