Malondialdehyde formation as an indicator of prostaglandin production by human platelets.
Malondialdehyde formation as an indicator of prostaglandin production by human platelets.
复制标题
丙二醛的形成作为人血小板产生前列腺素的指标。
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
Silver Mj
中科院分区：
文献类型：
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作者：
Smith Jb;C. Ingerman;Silver Mj
丙二醛的形成，前列腺素内过氧化物的代谢物，已经研究了富血小板血浆。少量产生于ADP、肾上腺素或胶原蛋白反应，大量产生于凝血酶反应。花生四烯酸诱导血小板产生大量丙二醛。阿司匹林或吲哚美辛可阻止血小板丙二醛的形成。富血小板血浆中丙二醛的测定可作为血小板前列腺素合成的指标，且比前列腺素测定简单。
The formation of malondialdehyde, a metabolite of prostaglandin endoperoxides, has been studied in platelet-rich plasma. Small amounts were produced in response to ADP, epinephrine, or collagen and larger amounts in response to thrombin. Arachidonic acid induced platelets to produce large amounts of malondialdehyde. Malondialdehyde formation by platelets was prevented by aspirin or indomethacin. The measurement of malondialdehyde in platelet-rich plasma may be used as an indicator of platelet prostaglandin synthesis, and is simpler than the measurement of prostaglandins.