VISUAL LEARNING SUPPRESSED BY COOLING THE TEMPORAL POLE
VISUAL LEARNING SUPPRESSED BY COOLING THE TEMPORAL POLE
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DOI：
10.1037/0735-7044.98.2.310
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发表时间：
1984-01-01
影响因子：
1.9
通讯作者：
SALSBURY, KG
中科院分区：
文献类型：
--
作者：
HOREL, JA;VOYTKO, ML;SALSBURY, KG
三只猴子，食蟹猴，被训练记住物体的彩色照片超过0，15，30和45秒的延迟。然后在颞叶前部9mm处植入2对冷却装置。该装置由3 × 104个电极组成。不锈钢管的10 mm环，冷却的甲醇可以泵入其中。一对（前对）覆盖颞尖的内侧部分（TG区），从鼻沟开始，向外侧延伸3 mm。第2对（后对）放置在前对外侧3 mm处，覆盖TG的其余部分和颞下回的前端，即TE前部。冷却任何一对探头在所有延迟产生赤字，但赤字是最长的延迟。冷却前对记忆和冷却后对记忆之间没有区别，只是冷却前对记忆大大增加了干扰刺激产生的回忆中断。当所有4个探头都被冷却时，这抑制了整个颞尖的功能，性能在所有延迟中都下降到偶然。而在这种情况下，动物不能学习新的视觉辨别，但他们可以执行以前学习的视觉辨别。颞极显然是储存短暂的顺行记忆的地方，内侧颞叶健忘症患者可以利用这种记忆。
Three monkeys, Macaca fasciculans, were trained to remember colored photographs of objects over delays of 0, 15, 30 and 45 s. Then 2 pairs of cooling devices were implanted bilaterally over the anterior 9 mm of the temporal lobe. The devices consisted of 3 .times. 10 mm loops of stainless steel tubing, into which cooled methanol could be pumped. One pair (anterior pair) covered the medial part of the temporal tip (area TG), starting at the rhinal sulcus and extending 3 mm laterally. The 2nd pair (posterior pair) was placed 3 mm lateral to the anterior pair, covering the rest of TG and the anterior extreme of the inferotemporal gyri, anterior TE. Cooling either pair of probes produced a deficit at all delays, but the deficit was greater at the longest delays. There was no difference between cooling the anterior pair and cooling the posterior pair, except that cooling the anterior pair greatly increased the disruption of recall that is produced by an interfering stimulus. When all 4 probes were cooled, which suppressed the function of the entire temporal tip, performance dropped to chance at all delays. While under this condition, the animals could not learn new visual discriminations, but they could perform previously learned visual discriminations. The temporal pole apparently is the store for the brief anterograde memory that is available to the medial temporal amnesics.