Method for the analysis of total fluoride in fluoride-releasing dental varnishes.
Method for the analysis of total fluoride in fluoride-releasing dental varnishes.
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释放氟化物的牙科清漆中总氟化物的分析方法。
DOI：
10.1159/000355613
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发表时间：
2014
期刊：
影响因子：
4.2
通讯作者：
Coleman,SS
中科院分区：
文献类型：
--
作者：
Carey,CM;Coleman,SS
当今的氟化物释放清漆（F清漆）含有各种各样的成分，这对测量其总氟化物含量提出了分析挑战。本研究报告了改进的方法来测量氟清漆中的氟含量。分析了单独含有二氟硅烷（0.1%F）或NaF（2.26%F）或与磷酸钙组合的六种不同的市售F-清漆。在小瓶中，分配1-3滴（0.05-0.15 g）清漆产品，溶解在氯仿中，在TISAB中平衡，并通过氟化物离子选择性电极分析。所有含NaF的氟清漆的氟化物平均重量百分比范围为2.03 - 2.24% F，在2.26% F的标示浓度的90%范围内。含二氟硅烷的产物的分析需要额外的水解步骤。ANOVA发现5%NaF清漆之间没有显著差异，p < 0.05。这种氟化物分析方法产生可靠和可重复的结果，并可用于各种F-清漆。该方法的标准不确定度为± 4%。该方法可能成为国家和国际标准的基础，以确保临床实践中使用的F-清漆产品具有产品文献中声明的氟化物含量。
Today's fluoride-releasing varnishes (F-varnish) contain a wide variety of ingredients which present analytical challenges for measuring their total fluoride content. This study reports improved methods to measure fluoride content in F-varnishes. Six different commercially available F-varnishes that contain difluorosilane (0.1% F) or NaF (2.26% F) alone or in combination with calcium-phosphates were analyzed. In a vial, 1-3 drops (0.05-0.15 g) of varnish product was dispensed, dissolved in chloroform, equilibrated in TISAB and analyzed via fluoride ion-selective electrode. The average weight percentage of fluoride for all F-varnishes containing NaF ranged from 2.03 to 2.24% F, which is within 90% of the declared label concentration of 2.26% F. Analysis of the difluorosilane-containing product required an additional hydrolysis step. ANOVA found no significant difference between the 5% NaF varnishes at p < 0.05. This method for fluoride analysis yields reliable and reproducible results and can be used for a wide variety of F-varnishes. The standard uncertainty for this method is ±4%. This method may become the basis for national and international standards that ensure the F-varnish products used in clinical practice have the fluoride content declared in the product literature.