Differential expression of glutathione S-transferase, glutathione peroxidase and glutathione reductase in normal and malignant human breast tissues.
Differential expression of glutathione S-transferase, glutathione peroxidase and glutathione reductase in normal and malignant human breast tissues.
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正常和恶性人乳腺组织中谷胱甘肽S-转移酶、谷胱甘肽过氧化物酶和谷胱甘肽还原酶的差异表达。
DOI：
10.1016/0304-3835(90)90229-q
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发表时间：
1990
期刊：
影响因子：
9.7
通讯作者：
Krishan,A
中科院分区：
文献类型：
--
作者：
Singh,SV;Brunnert,SR;Roberts,B;Krishan,A
In the present study we have compared the levels of glutathione (GSH) S-transferase, GSH peroxidase and GSH reductase in human breast tumors and adjacent normal tissues obtained from the same individuals. We have also quantitated GST π type antigen in these samples by western blotting. GST π activity towards 1-chloro-2,4-dinitrobenzene was found to be elevated in tumors from three out of six patients (patient nos. 2, 4 and 5), whereas this activity was suppressed in tumor from patient no. 1. Results of Western blotting using antibodies raised against GST π of human placenta were in agreement with the GST activity data. GSH peroxidase activity with cumene hydroperoxide as substrate was found to be elevated in four tumor samples (patients nos. 2, 4, 5, and 6) but suppressed in tumor from patient no. 1. On the other hand, GSH reductase activity was elevated in three samples (patients nos. 2, 4 and 5) and downregulated in the remaining three samples (patients nos. 1, 3 and 6). These results indicate that GSH-related enzymes are differentially altered in human breast tumors and GST π type isoenzyme(s), unlike certain other human carcinomas such as colonic, are not uniformly elevated in human breast tumors.
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人肝脏中五种谷胱甘肽 S-转移酶的纯化、亚基结构和免疫学特征，以及作为肝肿瘤标志物的酸性形式。
DOI：
--
发表时间：
1986
期刊：
Biochimica et Biophysica Acta
影响因子：
--
作者：
Yasushi Soma;Kimihiko Satoh;Kiyomi Sato
通讯作者：
Kiyomi Sato
大鼠谷胱甘肽转移酶亚基 7（肝癌标志物）的组织分布。
影响因子：
4.1
作者：
S. Pemble;J. Taylor;B. Ketterer
通讯作者：
B. Ketterer
人乳腺的谷胱甘肽转移酶与人胎盘和红细胞的转移酶密切相关。
DOI：
--
发表时间：
1986
期刊：
Biochemistry International
影响因子：
--
作者：
C. DiIlio;G. DelBoccio;R. Massoud;G. Federici
通讯作者：
G. Federici
分析过氧化物酶体增殖物诱导的大鼠肝脏肿瘤前和肿瘤病变中胎盘形式的谷胱甘肽 S-转移酶和 γ-谷氨酰转肽酶。
影响因子：
11.2
作者：
Rao,MS;Tatematsu,M;Subbarao,V;Ito,N;Reddy,JK
通讯作者：
Reddy,JK
谷胱甘肽转移酶催化形成的美法仑-谷胱甘肽加合物的表征。
影响因子：
5.8
作者：
Dulik,DM;Fenselau,C;Hilton,J
通讯作者：
Hilton,J