Using ethyl glucuronide in urine to detect light and heavy drinking in alcohol dependent outpatients.
Using ethyl glucuronide in urine to detect light and heavy drinking in alcohol dependent outpatients.
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DOI：
10.1016/j.drugalcdep.2015.10.004
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发表时间：
2015-12-01
影响因子：
4.2
通讯作者：
Ries RK
中科院分区：
文献类型：
--
作者：
McDonell MG;Skalisky J;Leickly E;McPherson S;Battalio S;Nepom JR;Srebnik D;Roll J;Ries RK
本研究调查了乙基葡萄糖醛酸苷免疫测定法（EtG-I）的临界值最能检测酒精依赖门诊患者5天内的重度饮酒与轻度饮酒。共有121名患有酒精使用障碍和合并精神疾病的成年人参加了酒精治疗研究。参与者提供自我报告的饮酒数据和尿液样本，每周三次，共16周（总样本= 2761）。在1至5天内计算低（100 ng/mL，200 ng/mL）和中等（500 ng/mL）EtG-I临界值与轻度（女性≤3标准饮酒量，男性≤ 4标准饮酒量）和重度饮酒（女性>3，男性>4标准饮酒量）之间的一致性。100 ng/mL的临界值检测到两天内>76%的轻度饮酒，五天内为66%。100 ng/mL的临界值检测到84%（1天）至79%（5天）的重度饮酒。200 ng/mL的截止值在5天内检测到>55%的轻度饮酒，在5天内检测到>66%的重度饮酒。500 ng/mL的临界值确定了一天内68%的轻度饮酒和78%的重度饮酒，此后轻度（2-5天<58%）和重度饮酒（2-5天<71%）的检测减少。相对于100 ng/mL，200 ng/mL和500 ng/mL临界值不太可能导致假阳性。100 ng/mL的EtG-I截止值最有可能检测到长达五天的大量饮酒和前两天的任何饮酒。≥ 500 ng/mL的临界值可能仅检测到前一天的重度饮酒。
This study investigated which ethyl glucuronide immunoassay (EtG-I) cutoff best detects heavy versus light drinking over five days in alcohol dependent outpatients. A total of 121 adults with alcohol use disorders and co-occurring psychiatric disorders taking part in an alcohol treatment study. Participants provided self-reported drinking data and urine samples three time per week for 16-weeks (total samples = 2761). Agreement between low (100 ng/mL, 200 ng/mL), and moderate (500 ng/mL) EtG-I cutoffs and light (women ≤3 standard drinks, men ≤ 4 standard drinks) and heavy drinking (women >3, men >4 standard drinks) were calculated over one to five days. The 100 ng/mL cutoff detected >76% of light drinking for two days, and 66% at five days. The 100 ng/mL cutoff detected 84% (1 day) to 79% (5 days) of heavy drinking. The 200 ng/mL cutoff detected >55% of light drinking across five days and >66% of heavy drinking across five days. A 500 ng/mL cutoff identified 68% of light drinking and 78% of heavy drinking for one day, with detection of light (2–5 days <58%) and heavy drinking (2–5 days <71%) decreasing thereafter. Relative to 100 ng/mL, the 200 ng/mL and 500 ng/mL cutoffs were less likely to result in false positives. An EtG-I cutoff of 100 ng/mL is most likely to detect heavy drinking for up to five days and any drinking during the previous two days. Cutoffs of ≥ 500 ng/mL are likely to only detect heavy drinking during the previous day.