Ecstasy (3,4-methylenedioxymethamphetamine) limits murine gammaherpesvirus-68 induced monokine expression.
Ecstasy (3,4-methylenedioxymethamphetamine) limits murine gammaherpesvirus-68 induced monokine expression.
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摇头丸（3,4-亚甲二氧基甲基苯丙胺）限制鼠伽马疱疹病毒 68 诱导的单核因子表达。
DOI：
10.1016/j.bbi.2008.01.002
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
Bost,KennethL
中科院分区：
文献类型：
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作者：
Nelson,DanielA;Nirmaier,JamieL;Singh,SamJ;Tolbert,MelanieD;Bost,KennethL
虽然摇头丸(3，4-亚甲基二氧基甲基苯丙胺，MDMA)已经被证明可以调节免疫反应，但还没有研究涉及药物诱导的病毒感染的改变。在这项研究中，骨髓来源的巨噬细胞暴露于MDMA，然后感染小鼠伽马疱疹病毒-68，并评估单因子的表达。MDMA诱导病毒刺激的Monokine mRNA表达减少，并呈剂量依赖关系。尤其是在感染了伽马疱疹病毒的巨噬细胞中，MDMA显著降低了IL-6mRNA的表达和分泌。能够减少单核细胞因子产生的MDMA浓度不会导致显著的细胞死亡，并允许正常的病毒基因表达。这些研究首次证明了这种滥用药物改变病毒诱导的巨噬细胞反应的能力。
While Ecstasy (3,4-methylenedioxymethamphetamine, MDMA) has been shown to modulate immune responses, no studies have addressed drug-induced alterations to viral infection. In this study, bone marrow-derived macrophages were exposed to MDMA, then infected with murine gammaherpesvirus-68, and the expression of monokines assessed. MDMA-induced reductions in virus-stimulated monokine mRNA expression were observed in a dose-dependent manner. In particular, IL-6 mRNA expression and secretion was significantly decreased in gammaherpesvirus-infected macrophages exposed to MDMA. Concentrations of MDMA capable of reducing monokine production did not induce significant cell death and allowed normal viral gene expression. These studies represent the first to demonstrate the ability of this drug of abuse to alter a viral-induced macrophage response.