Use of cyclodextrins in capillary electrophoresis for the chiral resolution of some 2-arylpropionic acid non-steroidal anti-inflammatory drugs
Use of cyclodextrins in capillary electrophoresis for the chiral resolution of some 2-arylpropionic acid non-steroidal anti-inflammatory drugs
复制标题
使用环糊精毛细管电泳手性拆分某些 2-芳基丙酸非甾体抗炎药
DOI：
10.1016/0021-9673(94)00945-6
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Z. Aturki
中科院分区：
文献类型：
--
作者：
S. Fanali;Z. Aturki
采用毛细管区带电泳法对非诺洛芬、布洛芬、氟比洛芬、苏洛芬、酮洛芬和吲哚洛芬等2-芳基丙酸类非甾体抗炎药（profens）的外消旋化合物进行了对映体分离。用衍生化的β-环糊精支撑背景电解质实现分离。环糊精的种类和浓度以及背景电解质的组成（pH和甲醇的量）影响络合和手性拆分。所采用的所有改性β-环糊精（庚-2,6-二- o-甲基-β-、庚-2,3,6-三- o-甲基-和6-甲氨基-β-环糊精）均与所测蛋白质具有良好的络合效果。三- o-甲基-β-环糊精被证明是最好的立体选择性添加剂，因为它可以对所研究的所有丙烯的对映体进行分离，而二甲基化和甲胺-β-环糊精只能分离部分丙烯。
The enantiomeric separation of racemic compounds of some 2-arylpropionic acid non-steroidal anti-inflammatory drugs (profens), namely fenoprofen, ibuprofen, flurbiprofen, suprofen, ketoprofen and indoprofen, was performed by capillary zone electrophoresis. The separation was obtained by supporting the background electrolyte with derivatized β-cyclodextrins. The type and concentration of cyclodextrin used and the background electrolyte composition (pH and amount of methanol) influenced the complexation and the chiral resolution. All the modified β-cyclodextrins used (heptakis-2,6-di-O-methyl-β-, heptakis-2,3,6-tri-O-methyl- and 6A-methylamino-β-cyclodextrin) showed good complexing effects with the profens tested. Tri-O-methyl-β-cyclodextrin proved to be the best stereoselective additive because it allowed the enantiomeric resolution of all the profens studied whereas the dimethylated and methylamino-β-cyclodextrin were able to separate only some of them.