Effect of sensitization of stereotypy on the acquisition and retention of tolerance to amphetamine hypophagia.
Effect of sensitization of stereotypy on the acquisition and retention of tolerance to amphetamine hypophagia.
复制标题
刻板印象的敏化对安非他明吞咽不足耐受性的获得和保留的影响。
DOI：
10.1007/bf02246451
复制
发表时间：
1996
影响因子：
3.4
通讯作者：
Hughes,KM
中科院分区：
文献类型：
--
作者：
Wolgin,DL;Hughes,KM
本研究的目的是确定先前的刻板印象致敏是否会干扰对安非他明引起的吞咽不足的耐受性的发展和保留。给大鼠间歇性注射苯丙胺（2.5 mg/kg）以诱导刻板敏化，或注射盐水。然后，每组的亚组每天注射安非他明 (2 mg/kg) 或盐水，并喝牛奶 30 分钟。致敏组和非致敏组对药物引起的吞咽功能障碍的耐受率和程度大致相同。这种耐受性伴随着在有牛奶的情况下进行刻板运动的频率的减少。然后在 4 周内每天对大鼠进行牛奶测试，不进行注射。随后的安非他明测试显示，两组人都失去了对药物引起的吞咽不足的耐受性，并且表现出比停药前更强烈的刻板印象。我们的结论是，间歇性注射安非他明（2.5 mg/kg）产生的定型敏化不会阻碍对药物引起的吞咽不足的耐受性的发展，并且不会改变大鼠抑制定型运动的能力。然而，停药后耐受性的丧失可能是由于更强烈的刻板印象的发展和/或“忘记”先前获得的抑制刻板印象的策略。
The purpose of this study was to determine whether prior sensitization of stereotypy interferes with the development and retention of tolerance to amphetamine-induced hypophagia. Rats were given intermittent injections of either amphetamine (2.5 mg/kg) to induce sensitization of stereotypy, or saline. Subgroups from each group then received daily injections of either amphetamine (2 mg/kg) or saline and access to milk for 30 min. Both sensitized and nonsensitized groups became tolerant to drug-induced hypophagia at about the same rate and to about the same extent. Such tolerance was accompanied by a decrease in the frequency of stereotyped movements while milk was available. The rats were then given daily milk tests for 4 weeks without injections. Subsequent tests with amphetamine revealed that both groups lost tolerance to druginduced hypophagia and displayed more intense stereotypy than they had prior to drug withdrawal. We conclude that sensitization of stereotypy produced by intermittent injections of amphetamine (2.5 mg/kg) does not retard the development of tolerance to druginduced hypophagia and does not alter the rat's ability to suppress stereotyped movements. However, the loss of tolerance following drug withdrawal may have been due to the development of more intense stereotypy and/or the “unlearning” of previously acquired strategies for suppressing stereotypy.