Exit from mycobacterial dormancy: a structural perspective.
Exit from mycobacterial dormancy: a structural perspective.
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退出分枝杆菌休眠：结构视角。
DOI：
10.2174/0929867322666150209153027
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发表时间：
2015
影响因子：
4.1
通讯作者：
R. Berisio
中科院分区：
文献类型：
--
作者：
F. Squeglia;A. Ruggiero;R. Berisio
分枝杆菌的休眠被定义为一种稳定但可逆的非复制状态，以应对压力。在结核分枝杆菌中，一种重要的人类病原体，这种状态是潜伏性结核病的原因。目前治疗结核病的化疗虽然能有效杀死生长中的结核杆菌，但在杀死休眠杆菌方面基本无效。由于这个原因，最近有兴趣开发新的药物来对抗这种潜伏形式的疾病。为此，了解细菌从休眠中复苏的分子基础是必要的，也是至关重要的。本文综述了分枝杆菌休眠退出的复杂机制的最新知识，负责分枝杆菌复苏休眠的主要分子球员进行了描述，并从结构的角度讨论了他们的作用。
Dormancy in mycobacteria is defined as a stable but reversible non-replicating state in response to stresses. In Mycobacterium tuberculosis, an important human pathogen, this state is responsible for latent Tuberculosis. The current chemotherapy to defeat Tuberculosis while effective in killing growing tubercle bacilli is largely ineffective in killing dormant bacilli. For this reason there is a recent interest to develop new drugs against this disease in the latent form. To this aim, the knowledge of the molecular basis of bacterial resuscitation from dormancy is necessary and of paramount importance. This review summarizes the current knowledge on the complex mechanism of exit from mycobacterial dormancy; the main molecular players responsible for mycobacterial resuscitation from dormancy are described and their role is discussed from a structural perspective.